What side effects are associated with this type of intervention?

The most common treatments for Tuberculosis involve a combination of antibiotics, including isoniazid, rifampin, ethambutol, and pyrazinamide. Known side effects of these medications can include liver toxicity, gastrointestinal disturbances, peripheral neuropathy, and hypersensitivity reactions. While nutritional supplements like Moringa powder, which have anti-inflammatory and antioxidant properties, are not standard treatments for TB, they may be used as adjunctive therapies to support overall health. However, their efficacy and safety in TB treatment specifically are not well-established.

What prior FDA approvals exist?

The FDA has primarily approved antibiotics such as isoniazid, rifampin, ethambutol, and pyrazinamide for the treatment of Tuberculosis. These drugs are the cornerstone of TB therapy and are used in combination to effectively treat the infection. While there is ongoing research into the potential benefits of nutritional supplements with anti-inflammatory and antioxidant properties, such as Moringa powder, there are no FDA-approved treatments for TB that fall into this category. Current TB treatment remains focused on antibiotic regimens.

What other types of research exist?

Caralluma fimbriata and resveratrol are promising alternatives to Moringa powder for TB patients. Caralluma fimbriata has shown positive health-ameliorating outcomes, while resveratrol is a naturally occurring antioxidant found in foods like red wine and grapes, with potential health benefits.

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Other

Moringa Powder Acceptability in Healthy Adults

N/A

Waitlist Available

Led By Susana Matias, PhD

Research Sponsored by University of California, Berkeley

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 7 days

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing Moringa leaf powder added to food or drinks in people without a specific disease. The goal is to find a safe and acceptable dose by testing different amounts. Moringa may help with blood sugar and cholesterol due to its nutrients and anti-inflammatory properties. Moringa oleifera leaves have been traditionally used in India as a hypocholesterolemic agent and have shown significant cholesterol-lowering effects in various studies.

Who is the study for?

This trial is for UC Berkeley staff aged 18-65 who can communicate in English or Spanish. It's designed to see how they feel about taking different amounts of Moringa powder every day.

What is being tested?

The study tests the acceptability of three doses of Moringa powder taken daily by healthy adults. Participants are randomly assigned to one of the dose groups: low, medium, or high.

What are the potential side effects?

Potential side effects from consuming Moringa powder may include digestive discomfort, allergic reactions, or changes in appetite but will vary based on individual tolerance and dose.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 7 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~7 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Acceptability

Consumption

Side effects

Secondary study objectives

Daily dose consumed

Other study objectives

Change in skin carotenoids

Taste

Texture

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: Moringa Powder - Medium DoseExperimental Treatment1 Intervention

Group A

Group II: Moringa Powder - Low DoseExperimental Treatment1 Intervention

Group C

Group III: Moringa Powder - High DoseExperimental Treatment1 Intervention

Group B

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Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The most common treatments for Tuberculosis (TB) include antibiotics such as isoniazid, rifampin, ethambutol, and pyrazinamide. These antibiotics work by targeting the Mycobacterium tuberculosis bacteria in different ways: isoniazid inhibits the synthesis of mycolic acids, essential components of the bacterial cell wall; rifampin inhibits RNA synthesis by targeting bacterial RNA polymerase; ethambutol disrupts cell wall formation by inhibiting arabinosyl transferases; and pyrazinamide disrupts membrane transport and energy production. These mechanisms are crucial for TB patients as they directly kill or inhibit the growth of the bacteria, thereby reducing the bacterial load and preventing the spread of the disease. Nutritional supplementation, such as Moringa powder, which has anti-inflammatory and antioxidant effects, may support TB treatment by enhancing the immune response and reducing inflammation, potentially improving overall patient outcomes.

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