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Gas Therapy

Carbon Dioxide for Coronary Artery Disease (NIMO-CAD Trial)

N/A
Waitlist Available
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adults > 18 years of age
Be older than 18 years old
Must not have
Significant non-coronary cardiac disease (e.g., valvular abnormality, or cardiomyopathy, etc.)
Inability to schedule the research study within 30 days of the SPECT/PET study and prior to any coronary revascularization procedure
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if using carbon dioxide can help measure blood flow in the hearts of people with heart disease.

Who is the study for?
This trial is for individuals with coronary artery disease. Specific eligibility criteria are not provided, but typically participants would need to meet certain health conditions and agree to the study's procedures.
What is being tested?
The trial is testing RespirAct, a method using carbon dioxide to assess blood flow in the coronary arteries. It's a pilot study focusing on how safe and feasible this technique is for patients with heart issues.
What are the potential side effects?
Since detailed side effects are not listed, generally speaking, introducing carbon dioxide might cause discomfort or changes in breathing patterns; however, specifics will be monitored during the trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am older than 18 years.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I do not have serious heart conditions like valve problems or cardiomyopathy.
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I can't join the study within 30 days after my SPECT/PET scan and before any heart vessel repair.
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I have a history of serious heart, lung, kidney, or liver disease.
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I have an irregular heartbeat.
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I cannot lie on my back for 60-90 minutes or have severe claustrophobia.
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My kidney function is suitable for MRI contrast.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Ratio of Maximum Signal Intensity (MSI) by BOLD MRI
Ratio of Maximum Signal Intensity (MSI) by FFP MRI

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Coronary Artery Disease (CAD) SubjectsExperimental Treatment1 Intervention
Subjects with a of coronary artery disease will undergo computer-controlled gas challenges.

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Who is running the clinical trial?

Indiana UniversityLead Sponsor
1,039 Previous Clinical Trials
1,219,028 Total Patients Enrolled
9 Trials studying Coronary Artery Disease
988 Patients Enrolled for Coronary Artery Disease
~20 spots leftby Jan 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
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