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Treatment for Microvascular Angina (DISCOVER INOCA Trial)

N/A
Recruiting
Led By Samit Shah, MD, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott Coroventis Coroflow Cardiovascular System, and to determine long-term outcomes.

Eligible Conditions
  • Microvascular Angina
  • Coronary Vasospasm
  • Ischemia
  • Nephrotic Syndrome
  • Endothelial Dysfunction
  • Chest Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Lesion length during the procedure
The proportion of subjects that exhibit mild, moderate or severe coronary artery stenosis
The proportion of subjects that experience Major Adverse Cardiovascular Events (MACE)
+1 more
Secondary outcome measures
Change from baseline in proportion of subjects that experience each classification of angina status during the study.
Proportion of subjects that experience Major Vascular Complications at any time during the study.
Proportion of subjects that experience a composite of death, stroke, and MI at any time during the study.
+14 more

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,907 Previous Clinical Trials
3,018,549 Total Patients Enrolled
1 Trials studying Microvascular Angina
31 Patients Enrolled for Microvascular Angina
AbbottIndustry Sponsor
752 Previous Clinical Trials
477,662 Total Patients Enrolled
2 Trials studying Microvascular Angina
665 Patients Enrolled for Microvascular Angina
Samit Shah, MD, PhDPrincipal InvestigatorYale University Medical School
~167 spots leftby Sep 2025
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