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tACS + Cognitive Exercises for Dementia (tACS Trial)
N/A
Waitlist Available
Research Sponsored by University of Manitoba
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Must not have
Diagnosis of Parkinson's, Parkinsonian dementia, Huntington disease, significant aphasia, intellectual disability, major depression, anxiety, bipolar disorder, schizophrenia or any other major mood disorder
Inability to adequately communicate in English
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (week 0), week 5, week 11, week 16
Summary
This trial tests a treatment that uses small electrical currents to stimulate the brain while participants play brain-training games. It targets older adults with cognitive decline to see if this approach can improve their brain function.
Who is the study for?
This trial is for English-speaking individuals with dementia or mild cognitive impairment. It's not suitable for those with Parkinson's, major mood disorders, epilepsy, severe vision/hearing issues, substance abuse disorder, or those in another dementia study. Participants shouldn't plan to change medications during the study.
What is being tested?
The trial tests transcranial alternative current stimulation (tACS) combined with cognitive exercises using an app. Participants are split into two groups; one starts with active tACS and ends with sham treatment after a break period while the other group does the opposite sequence.
What are the potential side effects?
Potential side effects of tACS may include discomfort at electrode sites, headache, fatigue or dizziness post-treatment. Cognitive exercises might cause mental fatigue but generally have minimal risks.
Eligibility Criteria
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have been diagnosed with a neurological or major mood disorder.
Select...
I cannot communicate well in English.
Select...
I have a history of epilepsy or seizures.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline (week 0), week 5, week 11, week 16
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (week 0), week 5, week 11, week 16
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change from baseline Wechsler Memory Scale (WMS-IV) Older Adult Battery Score at five, eleven and sixteen weeks.
Secondary study objectives
Electrovestibulography (EVestG)
Functional Near Infrared Spectroscopy (fNIRS)
N-back test
+3 moreTrial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Group 1 (G1)Experimental Treatment2 Interventions
Participants will receive active tACS simultaneously with cognitive exercises.
Group II: Group 2 (G2)Placebo Group1 Intervention
Participants will receive sham tACS simultaneously with cognitive exercises.
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Neuromodulation techniques like transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are common treatments for Mild Cognitive Impairment (MCI). TMS uses magnetic fields to induce electrical currents in specific brain regions, enhancing or inhibiting neuronal activity. tDCS applies a low electrical current to the scalp, modulating neuronal excitability.
These methods aim to improve cognitive functions by altering brain activity patterns, which is crucial for MCI patients as they experience cognitive decline. By targeting brain areas involved in memory and executive functions, these treatments can potentially slow down the progression of MCI and improve quality of life.
Find a Location
Who is running the clinical trial?
University of ManitobaLead Sponsor
621 Previous Clinical Trials
206,463 Total Patients Enrolled
Riverview Health Centre FoundationOTHER
5 Previous Clinical Trials
265 Total Patients Enrolled
Charis Senior Residences LP. DBA Aster GardensUNKNOWN
Media Library
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.