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Activating and Connecting Teens (ACT) Study (ACT Trial)

N/A
Waitlist Available
Led By Jessica L Jenness, MD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weekly throughout treatment (weeks 0-12) and at a 3-month follow-up (24 week)
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether Behavioral Activation, or BA, may be an alternative depression intervention for adolescents who have a history of Childhood Maltreatment, or CM. CM is defined as exposure to physical, sexual, or emotional abuse or physical or emotional neglect. This study will take an innovative approach integrating neural, behavioral, and novel mobile technologies to measure longitudinal change in reward processing as a mechanism of BA intervention response among depressed adolescents with a history of CM.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weekly throughout treatment (weeks 0-12) and at a 3-month follow-up (24 week)
This trial's timeline: 3 weeks for screening, Varies for treatment, and weekly throughout treatment (weeks 0-12) and at a 3-month follow-up (24 week) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Anhedonia/Activation
Depression
Other study objectives
Anxiety
Behavioral Problems
Ecological Momentary Assessment (EMA)
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Behavioral Activation ArmExperimental Treatment1 Intervention
See treatment description for information on Behavioral Activation. Participants will receive 12 weekly sessions of Behavioral Activation.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Behavioral Activation
2013
Completed Phase 3
~2900

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,826 Previous Clinical Trials
1,905,981 Total Patients Enrolled
86 Trials studying Depression
87,847 Patients Enrolled for Depression
Seattle Children's HospitalOTHER
310 Previous Clinical Trials
5,231,198 Total Patients Enrolled
7 Trials studying Depression
870 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,931 Previous Clinical Trials
2,745,002 Total Patients Enrolled
705 Trials studying Depression
260,887 Patients Enrolled for Depression
Jessica L Jenness, MDPrincipal InvestigatorUniversity of Washington
~4 spots leftby Dec 2025
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