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MDD with SI and No Attempt for Suicide

N/A
Recruiting
Led By Sakina Rizvi, PhD
Research Sponsored by Unity Health Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Summary

The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI), as well as the stability of markers over time.

Eligible Conditions
  • Suicide
  • Suicidal Thoughts
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Biomarkers for Suicide Risk

Trial Design

4Treatment groups
Experimental Treatment
Group I: MDD with no SI and Lifetime AttemptExperimental Treatment1 Intervention
Subjects with MDD and current MDE but no current suicidal ideation and a lifetime suicide attempt.
Group II: MDD with SI and Recent AttemptExperimental Treatment1 Intervention
Subjects with have MDD with current MDE, current suicidal ideation and a suicide attempt within the past 6 months
Group III: MDD with SI and No AttemptExperimental Treatment1 Intervention
Subjects will have MDD with current MDE, current suicidal ideation and no lifetime suicide attempts
Group IV: Healthy ControlsExperimental Treatment1 Intervention
Subjects will have no personal or family psychiatric history and no suicide attempts.

Find a Location

Who is running the clinical trial?

Unity Health TorontoLead Sponsor
554 Previous Clinical Trials
454,171 Total Patients Enrolled
6 Trials studying Suicide
507 Patients Enrolled for Suicide
Sakina Rizvi, PhDPrincipal InvestigatorUnity Health Toronto
5 Previous Clinical Trials
308 Total Patients Enrolled
2 Trials studying Suicide
167 Patients Enrolled for Suicide
~12 spots leftby Aug 2025
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