The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
KH
Overseen byKathleen Holton, MPH, PhD
Age: < 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: American University
No Placebo Group
Trial Summary
What is the purpose of this trial?
The study is investigating if following the low glutamate diet for 1 month, as compared to care as usual, can improve seizure frequency, severity, and duration; cognitive functioning; and/or quality of life in children with epilepsy.
Research Team
KH
Kathleen Holton, MPH, PhD
Principal Investigator
American University
Eligibility Criteria
Inclusion Criteria
4 or more seizures per month
Willing to keep all medications constant during the study.
All medications have remained constant for 30 days prior to study enrollment
See 1 more
Treatment Details
Interventions
- Low Glutamate diet (Other)
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Low Glutamate dietExperimental Treatment1 Intervention
Participants are put on the low glutamate diet for one month. The low glutamate diet reduces the consumption of free glutamate, while optimizing dietary micronutrient and antioxidant intake.
Group II: Wait-listed controlActive Control1 Intervention
Participants continue care as usual. All all medications must be kept constant during the study period, unless medically necessary.
Find a Clinic Near You
Who Is Running the Clinical Trial?
American University
Lead Sponsor
Trials
22
Recruited
5,600+
Children's National Research Institute
Collaborator
Trials
227
Recruited
258,000+
Michelle Riley-Brown
Children's National Research Institute
Chief Executive Officer since 2023
MHA from Washington University School of Medicine in St. Louis, Bachelor's degree from Tulane University
Catherine Bollard
Children's National Research Institute
Chief Medical Officer
MBChB, MD