Feeding Trial to Determine How Combinations of Different Dietary Bioactive Ingredients Influence High Density Lipoprotein (HDL) Metabolism (HDL Trial)

N/A

Waitlist Available

Led By Jennifer T Smilowitz, PhD

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0, 2, 4 hours

Summary

This trial involves participants drinking a special milkshake containing krill oil, dairy fats, lutein, and niacin. The study focuses on people with low levels of HDL cholesterol. Researchers will measure how these ingredients affect cholesterol metabolism by analyzing blood and urine samples. Krill oil has been studied for its effects on blood lipids, including lowering triglycerides and potentially affecting cholesterol levels.

Eligible Conditions

High cholesterol

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0, 2, 4 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0, 2, 4 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 2, 4 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Plasma lipoprotein profile

Secondary study objectives

Plasma HDL proteome

Red blood cell functionality

Urinary metabolomics

Trial Design

3Treatment groups

Active Control

Placebo Group

Group I: PC700, Krill Oil, and LuteinActive Control3 Interventions

Each shake delivers 30% of each participant's calculated energy expenditure and provides 45% energy as fat, 40% energy as carbohydrate and 15% energy as protein. The shake contains whipping cream, frozen fruit, glucose polymer, and protein powder. Fifty percent of the fat is made up of PC700. Additionally, 3.0g Krill oil and 40mg of lutein capsules are swallowed with water. Neptune Krill Oil capsules (Nutrigold); Lutein capsules (Jarrow Formulas); PC700 = dairy lipids (Fonterra brand)

Group II: PC700, Krill Oil, Lutein, and NiacinActive Control4 Interventions

Each shake delivers 30% of each participant's calculated energy expenditure and provides 45% energy as fat, 40% energy as carbohydrate and 15% energy as protein. The shake contains whipping cream, frozen fruit, glucose polymer, and protein powder. Fifty percent of the fat is made up of PC700. Additionally, 3.0g Krill oil and 40mg of lutein capsules are swallowed with water. Nicotinic acid was added to each shake prior to consumption at a doses 5mg/kg of body weight. Neptune Krill Oil capsules (Nutrigold); Lutein capsules (Jarrow Formulas); PC700 (Fonterra); Nicotinic acid (Natures Way)

Group III: Control ShakePlacebo Group1 Intervention

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