Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
Recruiting in Palo Alto (17 mi)
Overseen byArthur F Gelb, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Gelb, Arthur F., M.D.
No Placebo Group
Trial Summary
What is the purpose of this trial?
The purpose of this cross-sectional, observational study is to evaluate the site and mechanism(s) for expiratory airflow limitation in chronic, treated, current or former smokers (\>15 pack years) with COPD, Emphysema, and Asthma-COPD Overlap with mild to severe expiratory airflow limitation. Treatment may include short and long acting inhaled beta2agonists, short and long acting inhaled muscarinic receptor antagonists, inhaled and or oral corticosteroid, oral antibiotic, supplemental oxygen, and PDE type 4 inhibitor. In some cases, the patient may have had a history of asthma preceding the development of COPD (Asthma COPD Overlap).
Eligibility Criteria
Inclusion Criteria
COPD/ bronchitis and bronchiectasis in smokers with smoking history
emphysema in smokers with smoking history > 15 pack years
asthma- copd overlap
See 1 more
Treatment Details
Interventions
- Inhaled Corticosteroid (Corticosteroid)
- Long Acting Inhaled Beta2 Agonist (Bronchodilator)
- Long Acting Inhaled Muscarinic Receptor Antagonist (Bronchodilator)
- Oral Antibiotic (Antibiotic)
- Oral Corticosteroid (Corticosteroid)
- PDE Type 4 Inhibitor (Bronchodilator)
- Short Acting Inhaled Beta2 Agonist (Bronchodilator)
- Short Acting Inhaled Muscarinic Receptor Antagonist (Bronchodilator)
Participant Groups
1Treatment groups
Experimental Treatment
Group I: COPD, Emphysema, Asthma-COPD OverlapExperimental Treatment1 Intervention
Based on clinical, pathologic, laboratory, physiologic and radiologic differences, patient groups can be described.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Arthur F Gelb MDLakewood, CA
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Who Is Running the Clinical Trial?
Gelb, Arthur F., M.D.Lead Sponsor