What is the mechanism of action of this treatment?

Common treatments for Eosinophilic Esophagitis (EoE) include dietary management, proton pump inhibitors (PPIs), and topical corticosteroids. Dietary management involves eliminating allergens that trigger inflammation, while PPIs reduce acid production to help heal the esophageal lining. Topical corticosteroids directly reduce eosinophilic inflammation in the esophagus. These treatments are essential for EoE patients as they address the allergic and inflammatory processes, alleviating symptoms and preventing long-term esophageal damage.

What side effects are associated with this type of intervention?

Common treatments for Eosinophilic Esophagitis (EoE) include dietary management, proton pump inhibitors (PPIs), corticosteroids, and allergen-specific immunotherapy. Dietary management, such as elimination diets, can lead to nutritional deficiencies if not properly supervised. PPIs are generally well-tolerated but can cause headaches, diarrhea, and abdominal pain. Topical corticosteroids, like fluticasone or budesonide, can lead to oral thrush and, rarely, adrenal suppression. Allergen-specific immunotherapy, including oral immunotherapy (OIT) combined with anti-IgE treatments like omalizumab, can cause serious allergic reactions, including anaphylaxis, and may increase the risk of developing EoE. These treatments require careful monitoring to manage potential side effects effectively.

What prior FDA approvals exist?

As of now, the FDA has approved several treatments for Eosinophilic Esophagitis (EoE), focusing primarily on reducing inflammation and managing symptoms. These include corticosteroids like fluticasone and budesonide, which are commonly used to reduce esophageal inflammation. Additionally, proton pump inhibitors (PPIs) such as omeprazole are often prescribed to manage acid reflux, which can exacerbate EoE symptoms. While the study on detergents and their role in EoE pathogenesis is ongoing, it highlights the importance of understanding environmental factors in the management of EoE.

What other types of research exist?

Promising novel alternatives for treating Eosinophilic Esophagitis (EoE) in 2024 include biologics such as anti-IL-4 and anti-IL-13 antibodies (e.g., Dupilumab and Lebrikizumab), which target the inflammatory pathways involved in EoE. Additionally, dietary management strategies, such as elimination diets and the use of extensively hydrolyzed formulas, can help reduce allergen exposure and inflammation. Emerging therapies like epicutaneous immunotherapy and prebiotics/probiotics to modulate the immune response and improve gut health are also being explored.

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Household Detergents and Eosinophilic Esophagitis

N/A

Waitlist Available

Led By Benjamin Wright, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 15 minutes after teeth brushing

Awards & highlights

No Placebo-Only Group

Summary

This trial is studying whether detergents in products like toothpaste can make the esophagus lining leaky and cause allergic reactions. It focuses on people who might have allergic inflammation in their esophagus due to these detergents.

Who is the study for?

This trial is for healthy volunteers who can swallow pills. It's not for those with a history of esophageal diseases, swallowing difficulties, chronic abdominal issues, certain digestive disorders, gelatin allergies, recent use of SLS toothpaste or those who are pregnant.

What is being tested?

The study investigates if detergents like those in Colgate toothpaste contribute to allergic inflammation by making the esophagus lining leaky. Participants will undergo an Esophageal String Test and High Resolution Esophageal Manometry.

What are the potential side effects?

Potential side effects may include discomfort from swallowing the string used in EST or mild irritation from manometry procedures. Allergic reactions to ingredients in tested products could also occur.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 15 minutes after teeth brushing

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 15 minutes after teeth brushing

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 15 minutes after teeth brushing for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Mucosal impedance 15 minutes after exposure

Secondary study objectives

Change in IL-33 levels

Cardiography, Impedance

Change in Mucosal impedance 45 minutes after exposure

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Toothpaste detergents with Eosinophilic Esophagitis TestingExperimental Treatment3 Interventions

Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Esophageal String Test (EST)

2018

N/A

~30

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Eosinophilic Esophagitis (EoE) include dietary management, proton pump inhibitors (PPIs), and topical corticosteroids. Dietary management involves eliminating allergens that trigger inflammation, while PPIs reduce acid production to help heal the esophageal lining. Topical corticosteroids directly reduce eosinophilic inflammation in the esophagus. These treatments are essential for EoE patients as they address the allergic and inflammatory processes, alleviating symptoms and preventing long-term esophageal damage.