Household Detergents and Eosinophilic Esophagitis

Recruiting in Palo Alto (17 mi)

Overseen byBenjamin Wright, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is studying whether detergents in products like toothpaste can make the esophagus lining leaky and cause allergic reactions. It focuses on people who might have allergic inflammation in their esophagus due to these detergents.

Eligibility Criteria

This trial is for healthy volunteers who can swallow pills. It's not for those with a history of esophageal diseases, swallowing difficulties, chronic abdominal issues, certain digestive disorders, gelatin allergies, recent use of SLS toothpaste or those who are pregnant.

Inclusion Criteria

Normal, healthy volunteers

I can swallow pills.

Exclusion Criteria

Use of a toothpaste containing SLS within 2 weeks of the study

I have a diagnosed digestive or connective tissue condition.

Pregnancy

+3 more

Participant Groups

The study investigates if detergents like those in Colgate toothpaste contribute to allergic inflammation by making the esophagus lining leaky. Participants will undergo an Esophageal String Test and High Resolution Esophageal Manometry.

1Treatment groups

Experimental Treatment

Group I: Toothpaste detergents with Eosinophilic Esophagitis TestingExperimental Treatment3 Interventions

Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste.