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Light Therapy
Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy
N/A
Waitlist Available
Led By Alexander Rotenberg, MD, PhD
Research Sponsored by Boston Children's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 120 minutes
Awards & highlights
No Placebo-Only Group
Summary
This trial tests if shining green light on patients with hard-to-treat epilepsy can reduce their seizures. The light aims to change brain activity and improve their condition. Researchers will check if this method is safe and effective.
Eligible Conditions
- Intractable Epilepsy
- Epilepsy
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 120 minutes
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~120 minutes
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Effects of exposure to a narrow band of green light (520-540 nm) at low intensities (1-10 cd/m2) on the pattern of electrical activity in the cortex of epilepsy patients.
Secondary study objectives
To consider probable confounders, such as etiology and comorbidities, this information will be acquired through routine clinical care documentation by the study MD for (2)
To consider probable confounders, such as etiology and comorbidities, this information will be acquired through routine clinical care documentation by the study MD for (3)
To consider probable confounders, such as etiology and comorbidities, this information will be acquired with standardized NIH epilepsy data acquisition forms for (1)
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Open Label, Green Light ExposureExperimental Treatment1 Intervention
This is a single-center, open label, pilot feasibility study. Patients with epilepsy will be exposed to a narrow band of green light at low intensities (1-10 cd/m2). The investigators will record 30 minutes of scalp EEG prior to the light exposure and 30 minutes of scalp EEG recording post-light exposure. The number of epileptic spikes per minute at baseline will be compared to epileptic spike count per minute post-treatment, to determine whether green light exposure effectively decreases the number of epileptic spikes, in patients with ≥1 epileptic spike per minute at baseline.
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Who is running the clinical trial?
Boston Children's HospitalLead Sponsor
787 Previous Clinical Trials
5,582,505 Total Patients Enrolled
22 Trials studying Epilepsy
9,655 Patients Enrolled for Epilepsy
Alexander Rotenberg, MD, PhD4.04 ReviewsPrincipal Investigator - Boston Children's Hospital
Boston Children's Hospital
3 Previous Clinical Trials
230 Total Patients Enrolled
5Patient Review
Dr. Rotenberg is an excellent physician who always puts the needs of his patients first. Thank you!
Phillip Pearl, MDPrincipal InvestigatorBoston Children's Hospital