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Transcranial Magnetic Stimulation for Rolandic Epilepsy (TMS4BECTS Trial)

N/A

Recruiting

Led By Fiona M Baumer, MD

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of Benign Epilepsy with Centrotemporal Spikes (BECTS), sometimes called Rolandic Epilepsy. Diagnosis based on a history of a focal motor seizure or a seizure out of sleep AND an EEG with unilateral or bilateral centrotemporal spike waves

Be younger than 65 years old

Must not have

History of serious neurologic problems (i.e. history of other seizure disorder other than simple febrile seizure, head trauma with prolonged loss of consciousness, cerebrovascular accident or neuro-inflammatory disease)

Focal deficits on neurologic exam

Timeline

Screening 3 weeks

Treatment Varies

Follow Up before and after intervention (approximately 4 hours/visit on 2 study days one week apart)

Awards & highlights

No Placebo-Only Group

Summary

This trial will test if treating IEDs in children with epilepsy can improve language skills by using transcranial magnetic stimulation (TMS) to stimulate the brain region where the IEDs originate.

Who is the study for?

This trial is for English-speaking children diagnosed with Benign Epilepsy with Centrotemporal Spikes (BECTS), also known as Rolandic Epilepsy, based on specific seizure history and EEG results. It excludes those born prematurely (<35 weeks), with serious neurological issues, focal deficits in neuro exams, or abnormal MRI findings.

What is being tested?

The study tests transcranial magnetic stimulation (TMS) to see if it can improve language by treating brain activity disruptions caused by BECTS. Children will receive repetitive TMS (rTMS) to potentially reduce these disruptions and change how the motor cortex connects to language regions.

What are the potential side effects?

While rTMS is generally considered safe, potential side effects may include discomfort at the stimulation site, headache, lightheadedness, or rarely seizures. The impact on mood and cognition are also being studied.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with Rolandic Epilepsy based on my seizure history and EEG results.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had serious brain or nerve problems like seizures, severe head injuries, strokes, or diseases causing brain inflammation.

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I have specific areas of weakness or loss of function.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before and after intervention (approximately 4 hours/visit on 2 study days one week apart)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before and after intervention (approximately 4 hours/visit on 2 study days one week apart)

This trial's timeline: 3 weeks for screening, Varies for treatment, and before and after intervention (approximately 4 hours/visit on 2 study days one week apart) for reporting.