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Telephone-Based Support Programs for Epilepsy

N/A
Recruiting
Led By Tanya Spruill
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosed with epilepsy for at least one year
Adult (≥18 years of age)
Must not have
Active psychotic disorder (psychiatric diagnosis or antipsychotic medications in the EHR)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline visit, 3 month visit, 6 month visit, 12 month visit
Awards & highlights
No Placebo-Only Group

Summary

This trial is comparing two different ways to help people with epilepsy who have depression. One is called UPLIFT and the other is called BOOST. They will be compared to see which one is better at helping with depression symptoms, quality of life, and seizures.

Who is the study for?
This trial is for adults over 18 with epilepsy diagnosed at least a year ago, who speak English or Spanish and are experiencing mild to moderate depression. They must be willing to have their group phone sessions recorded. People with severe depression, suicidal thoughts, significant cognitive issues, or active psychotic disorders cannot participate.
What is being tested?
The study compares two telephone-based programs: UPLIFT (depression self-management) and BOOST (support groups), each lasting 8 weeks with one-hour weekly sessions. The goal is to see which program better reduces depressive symptoms and improves quality of life and seizure control in people with epilepsy over a year.
What are the potential side effects?
Since the interventions involve psychological support rather than medication, traditional side effects are not expected. However, participants may experience emotional discomfort discussing personal issues during sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with epilepsy for over a year.
Select...
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I do not have an active psychotic disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline visit, 3 month visit, 6 month visit, 12 month visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline visit, 3 month visit, 6 month visit, 12 month visit for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Presence of clinically significant depressive symptoms
Secondary study objectives
Change in depressive symptom severity
Change in disease-specific quality of life
Change in general health-related quality of life
+2 more
Other study objectives
Change in anxiety
Change in epilepsy self management
Change in healthcare utilization
+5 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm 1: UPLIFT (Using Practice and Learning to Increase Favorable Thoughts)Experimental Treatment1 Intervention
UPLIFT is a telephone-based depression self-management program for people with epilepsy.
Group II: Arm 2: BOOST (Bringing Out Our Strength Together)Active Control1 Intervention
BOOST is a telephone-based support program for people with epilepsy.

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,415 Previous Clinical Trials
856,257 Total Patients Enrolled
26 Trials studying Epilepsy
2,899 Patients Enrolled for Epilepsy
Tanya SpruillPrincipal InvestigatorNYU Langone Health
3 Previous Clinical Trials
134 Total Patients Enrolled
2 Trials studying Epilepsy
104 Patients Enrolled for Epilepsy
Daniel Friedman, MDPrincipal InvestigatorNYU Langone Health
1 Previous Clinical Trials
1,500 Total Patients Enrolled

Media Library

BOOST Clinical Trial Eligibility Overview. Trial Name: NCT05082181 — N/A
Epilepsy Research Study Groups: Arm 1: UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), Arm 2: BOOST (Bringing Out Our Strength Together)
Epilepsy Clinical Trial 2023: BOOST Highlights & Side Effects. Trial Name: NCT05082181 — N/A
BOOST 2023 Treatment Timeline for Medical Study. Trial Name: NCT05082181 — N/A
~21 spots leftby Aug 2025
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