Extended Antibiotics for Penile Prosthesis Infection
(CUPID Trial)

Recruiting in Palo Alto (17 mi)

Overseen bySarah Faris, MD

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: University of Chicago

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this study is to determine if an additional 6 days of oral antibiotics decreases the risk of penile prosthesis infection after implantation.

Eligibility Criteria

This trial is for males aged 35-90 with erectile dysfunction who are getting a specific penile prosthesis (AMS 700) and haven't used antibiotics in the last week. It's not for those with prior prostheses, urinary tract foreign bodies, urethral strictures, tuberculosis-related cystitis, recent chemotherapy, bladder surgery history or systemic neuromuscular diseases.

Inclusion Criteria

I am a man aged 35-90 with erectile dysfunction.

I am a male choosing a specific penile implant for erectile dysfunction as per guidelines.

Exclusion Criteria

I have had bladder inflammation due to Tuberculosis.

I have a condition like MS that affects bladder control.

Any protected population (i.e. Prisoners)

+6 more

Participant Groups

The study tests if taking oral antibiotics (Doxycycline, Augmentin, Bactrim or Ciprofloxacin) for an extra six days after implanting a penile prosthesis can reduce infection risk. Participants will receive one of these antibiotics to see which is most effective.

2Treatment groups

Active Control

Group I: No post-operative oral antibioticsActive Control1 Intervention

Patients will only receive 24hr of IV peri-operative antibiotics

Group II: 6 days of oral antibioticsActive Control4 Interventions

Patients will receive 24hr of IV peri-operative antibiotics and then 6 days of oral antibiotics