Retrospective Review of Esophageal Cancer at MSKCC
Recruiting in Palo Alto (17 mi)
DM
Overseen byDaniela Molena, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Memorial Sloan Kettering Cancer Center
No Placebo Group
Approved in 4 Jurisdictions
Trial Summary
What is the purpose of this trial?
Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.
Research Team
DM
Daniela Molena, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Eligibility Criteria
Inclusion Criteria
Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy
Pathologic staged T3 tumors (pT3)
Treatment Details
Interventions
- Esophagectomy (Surgery)
Participant Groups
3Treatment groups
Experimental Treatment
Group I: Circumferential resection margin (CRM)-closeExperimental Treatment1 Intervention
Participants will have a diagnosis of esophageal carcinoma and residual tumor \>0-1 mm from the CRM
Group II: Circumferential resection margin (CRM)+Experimental Treatment1 Intervention
Participants will have a diagnosis of esophageal carcinoma and residual tumor at the surgical CRM
Group III: Circumferential resection margin (CRM)Experimental Treatment1 Intervention
Participants will have a diagnosis of esophageal carcinoma and residual tumor \>1 mm from the CRM
Esophagectomy is already approved in Japan, China for the following indications:
Approved in Japan as Esophagectomy for:
- Resectable locally advanced squamous cell carcinoma (SCC) of the esophagus
Approved in China as Esophagectomy for:
- Resectable locally advanced squamous cell carcinoma (SCC) of the esophagus
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, NY
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Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Trials
1998
Patients Recruited
602,000+