Radiation Therapy for Bone Cancer
(TARGET-RT Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen bySahaja Acharya, MD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Disqualifiers: Brain metastases, Spinal cord compression, Pregnancy, others

No Placebo Group

Trial Summary

What is the purpose of this trial?This study is designed for children, adolescents and young adults undergoing radiation therapy for metastatic sarcoma. The aim of the study is to investigate if the investigators can improve the overall survival of these patients by targeting metastatic sites with radiation.

Eligibility Criteria

This trial is for children, adolescents, and young adults under 39 with metastatic sarcoma. They must have a performance score of at least 70 or an ECOG status of 0-1, indicating they can carry out daily activities without significant assistance. The cancer must be measurable on scans and may be newly diagnosed or progressive after initial treatment.

Inclusion Criteria

I am recommended to have radiation therapy as part of my second treatment plan.

I am part of Stratum A.

I am under 39 years old.

+6 more

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Induction Chemotherapy

Participants receive standard of care induction chemotherapy followed by restaging imaging

8-12 weeks

Consolidative Radiation Therapy (cRT)

Radiation/surgery to the primary site and radiation to all sites of metastatic disease

4-6 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 years

Participant Groups

The study tests the effectiveness of targeted radiation therapy (cRT) in improving survival for patients with metastatic soft tissue and bone sarcomas. It focuses on whether directing radiation to specific sites where the cancer has spread can benefit these younger patients.

2Treatment groups

Experimental Treatment

Active Control

Group I: Consolidative radiation therapy (cRT)Experimental Treatment1 Intervention

The therapeutic intervention in Stratum A is consolidative radiation therapy (cRT), which is defined as radiation/surgery to the primary site and radiation to all sites of metastatic disease. All patients enrolled in stratum A will receive standard of care (SOC) induction chemotherapy followed by restaging imaging prior to delivery of cRT.

Group II: standard of care (SOC)Active Control1 Intervention

Patients in Stratum B will undergo standard of care (SOC) second line systemic therapy with radiation to at least one disease site.