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Alkylating agents

Temozolomide Timing for Glioblastoma (TMZ-CHRONO Trial)

London, Canada

N/A

Waitlist Available

Led By Terry Ng, MD

Research Sponsored by Ottawa Hospital Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Completed post-operative brain RT

Completed maximal safe brain tumor resection

Must not have

Unable or unwilling to complete study questionnaires

Metastatic or incurable cancer other than IDH-wild type glioblastoma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up overall survival is determined at 5-years post-randomization.

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to see if taking a chemotherapy pill called Temozolomide (TMZ) at a specific time of day (morning or evening) is possible for adults with a type

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Who is the study for?

This trial is for adults with glioblastoma who have completed brain surgery and radiation. They must be able to take a chemotherapy pill called Temozolomide (TMZ) and keep a diary of when they take it. The study will exclude certain individuals based on criteria not specified here.Check my eligibility

What is being tested?

The study tests if the time of day TMZ is taken affects its effectiveness in treating glioblastoma. Participants are randomly assigned to take TMZ either in the morning or evening, and their health outcomes are monitored to plan for future larger trials.See study design

What are the potential side effects?

While specific side effects aren't listed here, typical side effects of Temozolomide can include fatigue, nausea, constipation, headache, and potential blood-related issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have finished treatment for my brain with radiation after surgery.

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I've had surgery to remove as much of my brain tumor as safely possible.

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I am 18 years old or older.

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I have been newly diagnosed with a specific type of brain cancer.

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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I cannot or do not want to fill out study questionnaires.

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My cancer is advanced and cannot be cured, but it's not IDH-wild type glioblastoma.

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Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the number of patients providing consent to participate will be collected during the recruitment period and the total number/proportion will be calculated upon completion of recruitment. the anticipated recruitment period length is one year.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the number of patients providing consent to participate will be collected during the recruitment period and the total number/proportion will be calculated upon completion of recruitment. the anticipated recruitment period length is one year.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the number of patients providing consent to participate will be collected during the recruitment period and the total number/proportion will be calculated upon completion of recruitment. the anticipated recruitment period length is one year. for reporting.