Soluble Arabinoxylan + Rice Bran for Gut Health in Healthy Adults

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Purdue University

Trial Summary

What is the purpose of this trial?The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes. Participants will: * Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period. * Provide blood and stool samples at six different time points. * Complete a food and gastrointestinal symptom diary during the intervention periods.

Eligibility Criteria

This trial is for healthy adults interested in contributing to research on gut health. Participants will consume fiber supplements and a placebo, provide blood and stool samples, and keep a food/symptom diary. Specific eligibility details are not provided.

Inclusion Criteria

Body mass index between 18.5 and 25 kg/m²

Able to read/speak English

I am either male or female.

+1 more

Exclusion Criteria

Currently on weight-loss diets

Smokers (100 cigarettes lifetime and current smoker)

Breastfeeding or pregnant women

+5 more

Participant Groups

The study tests the effects of soluble arabinoxylan fiber versus rice bran fiber on gut microbiota in comparison to a placebo (maltodextrin). It involves consuming each supplement for three weeks with breaks in between and monitoring changes.

3Treatment groups

Experimental Treatment

Placebo Group

Group I: Soluble ArabinoxylanExperimental Treatment1 Intervention

Participants in this arm will receive soluble arabinoxylan for 3 consecutive weeks.

Group II: Rice BranExperimental Treatment1 Intervention

Participants in this arm will consume rice bran fiber for 3 consecutive weeks.

Group III: MaltodextrinPlacebo Group1 Intervention

Participants in this arm will consume maltodextrin for 3 consecutive weeks.