Vascular Effects of Sertraline in Heart Failure
Recruiting in Palo Alto (17 mi)
Overseen byStuart Katz, MD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: Yale University
No Placebo Group
Approved in 2 Jurisdictions
Trial Summary
What is the purpose of this trial?To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression
Eligibility Criteria
Inclusion Criteria
Chronic heart failure with LVEF<40%, age >21 years
Depression requiring medical treatment with sertraline
Participant Groups
1Treatment groups
Experimental Treatment
Group I: AExperimental Treatment1 Intervention
Chronic heart failure patients with concomitant depression
Sertraline is already approved in United States, European Union for the following indications:
🇺🇸 Approved in United States as Zoloft for:
- Depression
- Obsessive-compulsive disorder (OCD)
- Panic disorder
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder (PMDD)
- Social anxiety disorder
🇪🇺 Approved in European Union as Sertraline for:
- Major depressive episodes
- Panic disorder
- Obsessive compulsive disorder
- Social anxiety disorder
- Post traumatic stress disorder
- Premenstrual dysphoric disorder
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Yale University School of MedicineNew Haven, CT
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Who Is Running the Clinical Trial?
Yale UniversityLead Sponsor
PfizerIndustry Sponsor