SyncAV CRT Programming for Heart Failure (SyncAV Trial)

Recruiting in Palo Alto (17 mi)

+104 other locations

Overseen ByNiraj Varma, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Abbott Medical Devices

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a special setting in heart devices called SyncAV ON to help patients with new heart devices. It aims to improve how well their hearts pump blood by adjusting the timing of electrical signals in the heart.

Eligibility Criteria

This trial is for adults with heart failure who have a specific ECG pattern, intact AV conduction, and are on optimal heart failure medication. They must be getting a new CRT device or upgrading to an Abbott CRT system without prior LV lead placement. Exclusions include recent heart issues, stroke, certain procedures within the last few months, persistent AF, pregnancy, limited life expectancy or other conflicting clinical trials.

Inclusion Criteria

I am scheduled for a new or upgraded CRT device implant without prior LV lead placement.

Exclusion Criteria

I have had a heart transplant or am considered a top priority for one.

I have or will have a His Bundle pacing device implanted.

I have had or plan to have heart vessel repair surgery recently.

Participant Groups

The SyncAV Post-Market Trial tests if setting CRT devices to 'SyncAV ON' improves heart function better than traditional fixed AV delay settings by observing changes in the left ventricle's size and function over time.

2Treatment groups

Experimental Treatment

Active Control

Group I: SyncAV ArmExperimental Treatment1 Intervention

Treatment Arm

Group II: Fixed AV Delay ArmActive Control1 Intervention

Control Arm