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Sodium Channel Blocker

Effect of Ranolazine on Echocardiographic Indices of Diastolic Dysfunction

N/A
Waitlist Available
Led By Anthony DeMaria, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Approved for 5 Other Conditions
All Individual Drugs Already Approved
No Placebo-Only Group

Summary

The purpose of this study is to evaluate the effects of ranolazine, an FDA-approved medication for the treatment of angina, on heart function by using echocardiography.

Eligible Conditions
  • Ranolazine
  • Tissue Doppler Ultrasound
  • Echocardiography
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2018 Phase 2 trial • 6 Patients • NCT02360397
17%
Syncopy
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ranolazine

Awards & Highlights

Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: 2Experimental Treatment1 Intervention
Placebo for 2 weeks, then washout for 2 weeks, then ranolazine for 2 weeks
Group II: 1Experimental Treatment1 Intervention
Active drug for 2 weeks, then washout period for 2 weeks, then placebo for 2 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ranolazine
FDA approved

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,188 Previous Clinical Trials
1,576,859 Total Patients Enrolled
Anthony DeMaria, MDPrincipal InvestigatorUCSD Medical Center
~1 spots leftby Dec 2025
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