Blood DNA Screening for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to establish "normal" values for a new blood and urine test that could aid in cancer screening. Researchers will collect blood and urine samples from participants and review their medical records to determine if these tests can accurately detect cancer signs. Individuals without a history of internal cancer and who have recently had negative screenings for conditions like colon and breast cancer might be suitable candidates. The study seeks a diverse group of participants, including those with conditions such as diabetes or chronic lung disease.
As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could enhance cancer screening methods.
Do I need to stop my current medications for the trial?
The trial protocol does not specify if you need to stop taking your current medications. However, it mentions that data on certain medications like anti-inflammatory drugs, statins, anti-hypertensives, and anti-depressants will be collected, so it's best to discuss your specific situation with the trial coordinators.
What prior data suggests that these tests are safe for cancer screening?
Research shows that the NOMAD Study Blood Test offers a new method to screen for multiple cancers using blood samples. Previous studies have found it can detect various cancers by identifying substances released by cancer cells into the blood. Importantly, these studies have not reported any major safety issues, indicating the test is well-tolerated.
For the NOMAD Study Urine Test, similar research shows promising results in detecting cancers through urine samples. One study accurately detected prostate cancer using a urine test. Other studies suggest it is reliable and safe, with no major side effects reported.
Both the blood and urine tests are designed to be minimally invasive, reducing the likelihood of discomfort or harm. Overall, the available data suggest these tests are generally safe for participants.12345Why are researchers excited about this trial?
Researchers are excited about the NOMAD approach to cancer screening because it uses a novel molecular method to analyze DNA from blood samples. Unlike traditional cancer screenings, which often rely on imaging or invasive procedures, this method aims to detect cancer with a simple blood test, making it less invasive and potentially more accessible. The goal is to improve early detection by identifying specific DNA markers associated with cancer, which could lead to earlier and more accurate diagnoses. By focusing on blood DNA, the NOMAD method could revolutionize how we screen for cancer, offering a more convenient and possibly more precise alternative to current practices.
What evidence suggests that the NOMAD Study Blood Test and Urine Test could be effective for cancer screening?
Research has shown that the NOMAD Study Blood Test, which participants in this trial will undergo, is promising for detecting over 50 types of cancer. It accurately identifies individuals without cancer 99.6% of the time. Additionally, it correctly determines the cancer's origin 91.7% of the time and detects cancer in 73.7% of cases.
For the NOMAD Study Urine Test, also part of this trial, early results suggest effectiveness for certain cancers. One study found it reliably rules out bladder cancer in 97.6% of individuals without it. Another study showed it accurately identified prostate cancer 91% of the time. These tests could aid in early cancer detection and diagnosis.12678Who Is on the Research Team?
John B. Kisiel, M.D.
Principal Investigator
Mayo Clinic in Rochester
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
Patients undergo blood and urine sample collection on study. Patients' medical records are reviewed.
Follow-up
Participants are monitored for safety and effectiveness after sample collection
What Are the Treatments Tested in This Trial?
Interventions
- NOMAD Study Blood Test
- NOMAD Study Urine Test
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo blood and urine sample collection on study. Patients' medical records are reviewed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
Citations
NCT06192875 | A Novel Molecular Approach to Blood ...
This study is being done to establish "normal' values for a new blood test and urine test approach to cancer screening. Patients undergo blood and urine sample ...
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A Study of a New Molecular Approach to Blood DNA ...
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Exciting results from blood test for 50 cancers
A blood test for more than 50 types of cancer could help speed up diagnosis, according to a new study. Results of a trial in North America show that the ...
MCED blood test demonstrates high specificity, strong ...
The test showed high specificity (99.6%), positive predictive value (61.6%), and accurate cancer origin prediction (91.7%). Sensitivity was 73.7 ...
6.
hopkinsmedicine.org
hopkinsmedicine.org/news/newsroom/news-releases/2020/04/first-study-of-multicancer-blood-test-to-screen-for-cancer-guide-interventionFirst study of multicancer blood test to screen for cancer ...
Overall, 26 cancers were detected by the blood test while an additional 24 cancers were detected by standard screening such as mammography or ...
Case Report: Multi-cancer early detection utilizing blood ...
Multi-cancer early detection (MCED) genomic tests are being developed that allow for blood-based screening of multiple cancers simultaneously.
Fred Hutch leads new Vanguard Study for Cancer ...
Multi-cancer detection tests use blood samples to detect biological substances released in the bloodstream by cancer cells or in human DNA. Each ...
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