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Personalized Medicine for Canadians With Hemophilia (PMCH Trial)

N/A
Recruiting
Led By Alfonso Iorio, MD, PhD, FRCPC
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at study enrollment and at 2 years at study completion.
Awards & highlights
No Placebo-Only Group

Summary

This trial will assess the impact of adopting population PK (popPK) based tailored prophylaxis in clinical practice, including proportion of patients eligible for tailoring, and encountered barriers.

Eligible Conditions
  • Hemophilia A
  • Hemophilia B

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at study enrollment and at 2 years at study completion.
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at study enrollment and at 2 years at study completion. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Annualized Bleeding Rate (ABR) pre and post-tailoring implementation
Change in patient quality of life
Secondary study objectives
Adherence to prescribed regimen
Assessment of the predictive performance of the WAPPS-Hemo clinical calculator
Change in joint function
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Tailored RegimenExperimental Treatment1 Intervention
Implementation of WAPPS-Hemo personalized dosing regimen.

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
918 Previous Clinical Trials
2,615,693 Total Patients Enrolled
2 Trials studying Hemophilia A
1,400 Patients Enrolled for Hemophilia A
Alfonso Iorio, MD, PhD, FRCPCPrincipal InvestigatorMcMaster University

Media Library

WAPPS-Hemo (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03615053 — N/A
WAPPS-Hemo (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03615053 — N/A
Hemophilia A Clinical Trial 2023: WAPPS-Hemo Highlights & Side Effects. Trial Name: NCT03615053 — N/A
Hemophilia A Research Study Groups: Tailored Regimen
~95 spots leftby Dec 2025
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