Maternal-fetal Immune Responses to Fetal Surgery

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byMauro Schenone, MD

Age: 18 - 65

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?

Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the effectiveness of these procedures. The investigators aim to understand the effects of surgery on the maternal and fetal immune system and whether immune activation may be causing some of these infants to be born prematurely.

Research Team

Mauro Schenone, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

Maternal age ≥18 years

Pregnant with a congenital anomaly diagnosis AND undergoing fetal intervention in utero

Delivery planned at Mayo Clinic, Rochester MN

See 1 more

Treatment Details

Interventions

Blood and placenta specimen collection (Other)

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Fetal surgical intervention groupExperimental Treatment1 Intervention

Pregnant adult women carrying a fetus with a diagnosed congenital anomaly and scheduled to undergo fetal surgical intervention at Mayo Clinic.

Group II: Control group - normal pregnancyExperimental Treatment1 Intervention

Pregnant adult women with normal ultrasound findings. These women will be matched with the subjects enrolled in the intervention cohort for parity, maternal age, ethnicity, fetal sex and gestational age at time of surgical intervention.