TXTXT Intervention for HIV Adherence

Recruiting in Palo Alto (17 mi)

+11 other locations

Overseen byAmy Johnson, PhD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?This trial tests if sending text message reminders can help young people with HIV stick to their medication and keep the virus levels low. The study focuses on youth and young adults who often forget to take their medicine. The text messages serve as reminders to help them stay on track with their treatment.

Eligibility Criteria

This trial is for young people aged 16-35 with HIV who are on antiretroviral therapy (ART) but have a viral load of ≥200c/mL or haven't been taking their medication regularly. They must be able to get text messages and give informed consent, and they should already be patients at one of the participating clinics.

Inclusion Criteria

Have a viral load ≥200c/mL and/or report poor adherence (<90% of pills taken in the last 30 days)

Current patient of a participating clinic

Can provide informed consent for research component

+3 more

Exclusion Criteria

Participant is participating in another study related to ART adherence

I am not between the ages of 16 and 35.

I am unable to understand and give consent for treatment.

Participant Groups

The study compares two groups in different clinics: one gets standard HIV care, while the other receives an additional text message-based intervention called TXTXT aimed at improving medication adherence. The effectiveness will be measured by how well participants stick to their ART regimen and their viral load after 3 and 6 months.

2Treatment groups

Experimental Treatment

Active Control

Group I: InterventionExperimental Treatment1 Intervention

Clinics randomized to the intervention arm will have participants complete a 6-month intervention period. Clinics will sign up eligible participants to receive automated SMS messages from the Dimagi CommCare platform during the participant's baseline study visit. Participants will have the option to tailor the message content based on their own preferences and will be able to select to receive messages in English or in Spanish, the time the messages are delivered, and frequency of messages. Clinic staff will enter this information in the Dimagi CommCare platform, and then test receipt of text messages by the participant before they complete this baseline visit.

Group II: ComparisonActive Control1 Intervention

Clinics randomized to the comparison arm will have participants receive standard of care ART adherence support for 3 months, and will receive the TXTXT intervention for 3 months. The standard of care for ART adherence across clinic sites consists of routine follow-up from assigned case managers for appointment reminders and adherence counseling at scheduled visits .