← Back to Search

Magnetic Resonance Elastography for Hydrocephalus

N/A

Waitlist Available

Led By Keith D Paulsen, PhD

Research Sponsored by Dartmouth-Hitchcock Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 15 years

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a new magnetic resonance technique to see if it can help diagnose normal pressure hydrocephalus without needing invasive procedures.

Who is the study for?

This trial is for adults over 21 with adult onset hydrocephalus, which includes conditions like normal pressure hydrocephalus. Participants should have symptoms such as memory issues, urinary incontinence, or walking problems and enlarged ventricles on brain scans. It's not for those with pacemakers, pregnancy, severe organ dysfunction or diseases that make surgery too risky.

What is being tested?

The study tests a new MRI technique called magnetic resonance elastography (MRE) to see if it can better identify hydrocephalus compared to standard MRI by looking for unique patterns in the brain that indicate the disease.

What are the potential side effects?

Since MRE is a diagnostic imaging technique similar to regular MRIs but measuring tissue stiffness, side effects are minimal but may include discomfort from lying still during the scan or loud noises from the machine.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 15 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~15 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 15 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Mean shear modulus

Secondary study objectives

Pre-operative (and pre-drain placement) shear modulus in the experimental group will be compared with various assessments of clinical improvement after VP shunting.