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The Hypotensive Effects of Home-Based Isometric Handgrip Training in Older Adults With Pre-Hypertension and Hypertension - The HoldAge Trial

N/A
Waitlist Available
Led By Alberto J Alves, PhD
Research Sponsored by University Institute of Maia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
-
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 2 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if squeezing a handgrip device can help lower blood pressure in older adults with high blood pressure. The exercise aims to make blood vessels more flexible, which could reduce blood pressure over time. Handgrip exercise has been studied for its potential to reduce blood pressure, with mixed results depending on the intensity and supervision of the exercise.

Eligible Conditions
  • High Blood Pressure
  • Hypertension

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to 2 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 2 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Aerobic fitness
Arterial Stiffness
Endothelial cell repair/damage
+6 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Isometric Handgrip TrainingExperimental Treatment1 Intervention
The 8-week exercise program will include three sessions of isometric handgrip training per week
Group II: Aerobic Exercise TrainingActive Control1 Intervention
The 8-week exercise program will include three sessions of aerobic exercise per week
Group III: Control GroupActive Control1 Intervention
The control group will receive usual medical care

Find a Location

Who is running the clinical trial?

University Institute of MaiaLead Sponsor
14 Previous Clinical Trials
775 Total Patients Enrolled
Aveiro UniversityOTHER
56 Previous Clinical Trials
6,687 Total Patients Enrolled
Hospital Infante D. Pedro, Centro Hospitalar Do Baixo VougaUNKNOWN
Hospital Pedro Hispano, ULS MatosinhosUNKNOWN
Porto UniversityUNKNOWN
University of ConnecticutOTHER
190 Previous Clinical Trials
160,779 Total Patients Enrolled
Unidade de Saúde Familiar de Santa JoanaUNKNOWN
Research Center in Sports Sciences, Health Sciences and Human DevelopmentUNKNOWN
1 Previous Clinical Trials
46 Total Patients Enrolled
Unidade de Saúde Familiar SerzedeloUNKNOWN
Alberto J Alves, PhDPrincipal InvestigatorCIDESD, University Institute of Maia, Maia, Portugal
~18 spots leftby Dec 2025
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