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Diuretic

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

N/A
Waitlist Available
Led By Madhav Thambisetty, MD, PhD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (a median of 114 days)
Awards & highlights
No Placebo-Only Group

Summary

This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.

Eligible Conditions
  • High Blood Pressure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (a median of 114 days)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (a median of 114 days) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Time to dementia onset
Secondary study objectives
Time to Alzheimer's disease onset

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: TriamtereneExperimental Treatment1 Intervention
Reference group
Group II: AmilorideExperimental Treatment1 Intervention
Exposure group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Amiloride
2013
Completed Phase 4
~1080

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,670 Previous Clinical Trials
11,731,596 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,805 Previous Clinical Trials
28,048,187 Total Patients Enrolled
Rutgers UniversityOTHER
121 Previous Clinical Trials
2,662,684 Total Patients Enrolled
Johns Hopkins UniversityOTHER
2,339 Previous Clinical Trials
14,734,961 Total Patients Enrolled
Madhav Thambisetty, MD, PhDPrincipal InvestigatorNational Institute on Aging (NIA)
13 Previous Clinical Trials
2,515,270 Total Patients Enrolled
~34511 spots leftby Jan 2026
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