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Thyroid Hormone Replacement
Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment (DTE Trial)
N/A
Waitlist Available
Research Sponsored by Walter Reed National Military Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
* Patients will be between the ages of 18 to 65 and will have been on levothyroxine for primary hypothyroidism for at least 6 months.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 months
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions
No Placebo-Only Group
Summary
Our hypothesis is that hypothyroid patients on DTE may have a decrease in symptoms, an improvement of cognitive function, and an increase in sense of well-being/ quality of life equivalently compared with L-T4.
Eligible Conditions
- Hypothyroidism
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 4 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Wechsler Memory Scale-Version IV (WMS-IV)
thyroid-symptom questionnaire
Secondary study objectives
Biochemical measures
Other study objectives
Beck Depression Index
Clinical preference
General health questionnaire-12
Awards & Highlights
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Active Control
Group I: LevothyroxineActive Control1 Intervention
Levothyroxine in the capsule form, once daily, appropriate dosage to keep TSH at the normal range.
Group II: Desiccated thyroid extractActive Control1 Intervention
Desiccated thyroid extract in capsule form, once daily, appropriate dosage to keep TSH in the normal range.
Find a Location
Who is running the clinical trial?
Walter Reed National Military Medical CenterLead Sponsor
143 Previous Clinical Trials
33,147 Total Patients Enrolled
1 Trials studying Hypothyroidism
81 Patients Enrolled for Hypothyroidism