INSPIRE Stewardship Bundle for Skin and Soft Tissue Infections

Recruiting in Palo Alto (17 mi)

+101 other locations

Overseen by Richard Platt, MD, MS

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Harvard Pilgrim Health Care

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial tests a computer system that helps doctors choose the right antibiotics for adults with skin infections by predicting if the infection will resist common treatments.

Research Team

Shruti Gohil, MD, MPH

Principal Investigator

UC Irvine Division of Infectious Diseases

Susan Huang, MD, MPH

Principal Investigator

UC Irvine Division of Infectious Diseases

Richard Platt, MD, MS

Principal Investigator

Harvard Pilgrim Health Care Institute/Harvard Medical School

Eligibility Criteria

The INSPIRE trial is for HCA Healthcare hospitals using MEDITECH electronic health records, admitting non-critically ill adults with skin and soft tissue infections. It's not about individual patients but the hospital practices.

Treatment Details

Interventions

• INSPIRE CPOE Smart Prompt for Skin and Soft Tissue Infection (Behavioural Intervention)
• INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection (Behavioural Intervention)
• Routine Care (Behavioural Intervention)

Trial Overview This study compares routine care against a new 'Stewardship Bundle' that uses smart software prompts to guide antibiotic use, aiming to improve treatment by predicting resistant infections in real-time.

Participant Groups

Group I: Arm 2: INSPIRE Stewardship Bundle Active Control 1 Intervention

Use of computerized physician order entry (CPOE) smart prompts, clinician feedback, and activities to support CPOE adoption (including education and alignment of CPOE workflows) to guide empiric choice of antibiotics for skin/soft tissue infection in the first 3 days of hospitalization.

Group II: Arm 1: Routine Care Active Control 1 Intervention

Continuation of routine antibiotic stewardship strategies.

Who Is Running the Clinical Trial?

Harvard Pilgrim Health Care

Lead Sponsor

Trials

61

Recruited

27,990,000+

Cain Hayes

Harvard Pilgrim Health Care

Chief Executive Officer since 2021

MBA from Webster University

Michael Sherman

Harvard Pilgrim Health Care

Chief Medical Officer since 2018

MD from Yale School of Medicine

Hospital Corporation of America

Industry Sponsor

Trials

8

Recruited

3,433,000+

University of California, Irvine

Collaborator

Trials

580

Recruited

4,943,000+

Chad T. Lefteris

University of California, Irvine

Chief Executive Officer since 2019

MBA from University of California, Irvine

Michael J. Stamos

University of California, Irvine

Chief Medical Officer since 2019

MD, PhD from University of California, Irvine

HCA Healthcare, Inc

Collaborator

Trials

2

Recruited

200+

University of Massachusetts, Amherst

Collaborator

Trials

83

Recruited

3,474,000+

Martin T. Meehan

University of Massachusetts, Amherst

Chief Executive Officer since 2015

J.D. from Suffolk University Law School

Dr. Mark Klempner

University of Massachusetts, Amherst

Chief Medical Officer since 2012

MD from McGill University

Brigham and Women's Hospital

Collaborator

Trials

1,694

Recruited

14,790,000+

Dr. William Curry

Brigham and Women's Hospital

Chief Medical Officer

MD from Columbia University College of Physicians and Surgeons

Dr. Scott Schissel

Brigham and Women's Hospital

Chief Executive Officer since 2021

MD from Columbia University College of Physicians and Surgeons

Rush University

Collaborator

Trials

46

Recruited

3,294,000+