Smart Prompt System vs Routine Care for Urinary Tract Infection

Palo Alto (17 mi)

Overseen bySusan Huang, MD, MPH

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Harvard Pilgrim Health Care

No Placebo Group

Trial Summary

What is the purpose of this trial?The INSPIRE-ASP UTI trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with UTI is infected with a resistant pathogen. Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized.

Eligibility Criteria

The INSPIRE-ASP UTI Trial is for HCA hospitals that use MEDITECH electronic health record systems and admit non-critically ill adults with urinary tract infections. Individual patients are not directly enrolled; instead, the trial involves 59 hospitals.

Treatment Details

This trial compares usual antibiotic stewardship practices against a new approach using smart prompts in the hospital's computerized order entry system to predict resistance to antibiotics in adult UTI patients.

2Treatment groups

Active Control

Group I: INSPIRE CPOE Smart PromptActive Control1 Intervention

Use of a computerized physician order entry (CPOE) smart prompt alert to guide empiric choice of antibiotics for UTI in non-ICU patients in the first 3 days of hospitalization.

Group II: Routine CareActive Control1 Intervention

Continued routine antibiotic stewardship strategies.