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Genetic Testing

Mosaic Embryo Transfer for Infertility

N/A

Recruiting

Led By Mandy Katz-Jaffe, PhD

Research Sponsored by Colorado Center for Reproductive Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Women age 18-45

Women age 18-45 Infertile women who have completed an IVF cycle with PGT at the Colorado Center for Reproductive Medicine (CCRM) that have a mosaic embryo

Must not have

Embryonic mosaic PGT results that include chromosome errors 13, 18, 21

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12-15 months after birth of baby

Awards & highlights

No Placebo-Only Group

Summary

This trial looks at whether it's safe to transfer a mosaic embryo that's been screened for genetic abnormalities.

Who is the study for?

This trial is for women aged 18-45 who are infertile and have completed an IVF cycle with PGT at CCRM, possessing a mosaic embryo. They must be willing to transfer only one embryo and meet the clinic's standards for an embryo transfer. It excludes those desiring multiple embryos, using gestational carriers, or having certain chromosomal errors.

What is being tested?

The study investigates the outcomes of transferring a single mosaic embryo (with both normal and abnormal cells) after preimplantation genetic testing in infertile women. The focus is on understanding the success rate and potential risks associated with such transfers.

What are the potential side effects?

As this trial involves the transfer of a mosaic embryo during IVF, side effects may include typical IVF-related discomforts like cramping or bloating; however, specific risks related to carrying a mosaic embryo will be closely monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a woman aged between 18 and 45.

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I am a woman aged 18-45, infertile, completed IVF with PGT at CCRM, and have a mosaic embryo.

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I am willing to have a single embryo transferred.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My embryo's genetic test shows abnormalities in chromosomes 13, 18, or 21.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12-15 months after birth of baby

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12-15 months after birth of baby

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12-15 months after birth of baby for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Evaluation of Implantation rate

Live birth rate

Secondary study objectives

Miscarriage Rates

Neonatal Outcomes

Pregnancy complications

+3 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Transfer of mosaic embryoExperimental Treatment1 Intervention

Women will have a mosaic embryo transferred to their uterus after in vitro fertilization (IVF) with pre implantation genetic testing completed at Colorado Center for Reproductive Medicine.

0 / 4Eligibility criteria met