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Mental Stress & Diesel Exhaust on Cardiovascular Health (DESTRESS Trial)

N/A

Waitlist Available

Led By Anjum Hajat, PhD

Research Sponsored by University of Washington

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change in blood pressure from baseline (pre-exposure) to 60 minutes post exposure

Awards & highlights

No Placebo-Only Group

Summary

This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.

Eligible Conditions

Inflammation and Pain
Catecholamines
High Blood Pressure
Inflammation

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change in dopamine from baseline (pre-exposure) to immediately after exposure

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change in dopamine from baseline (pre-exposure) to immediately after exposure

This trial's timeline: 3 weeks for screening, Varies for treatment, and change in dopamine from baseline (pre-exposure) to immediately after exposure for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in dopamine

Change in epinephrine

Change in norepinephrine

Secondary study objectives

Change in d-dimer

Change in fibrinogen

Change in interleukin-1b (IL-1b)

+2 more

Other study objectives

Change in blood pressure

Change in heart rate

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Active Control

Group I: Diesel Exhaust and stressActive Control2 Interventions

Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed and are subject to a mental stress test (TSST) which involves a public speaking and math task.

Group II: TSST/Stress onlyActive Control1 Intervention

Subjects undergo a mental stress test, known as the Trier Social Stress Test (TSST), which involves a public speaking and math task.

Group III: Diesel ExhaustActive Control1 Intervention

Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed.

Group IV: Filtered AirActive Control1 Intervention

Subjects sit in a room for two hours breathing in filtered air which resembles levels of air pollution found in the ambient environment

0 / 1Eligibility criteria met