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Vitamin K2 Supplement

Low-Dose Vitamin K2 (90-mcg/d) for Insulin Resistance

N/A
Waitlist Available
Led By Norman K Pollock, Ph.D.
Research Sponsored by Augusta University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline in insulin sensitivity at 8 weeks

Summary

Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K manipulation on carboxylation of osteocalcin and its subsequent effect on glucose metabolism in clinical trials. The purpose of this randomized, double-blind, placebo-controlled clinical trial in adults is to determine whether eight weeks of daily supplementation with vitamin K2 (menaquinone-7) can improve markers in blood associated with diabetes risk.

Eligible Conditions
  • Insulin Resistance
  • Obesity
  • Type 1 Diabetes
  • Prediabetes

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline in beta-cell function at 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline in beta-cell function at 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in beta-cell function
Change in insulin sensitivity
Secondary study objectives
Change in arterial stiffness (PWV)
Body Weight Changes

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Low-Dose Vitamin K2 (90-mcg/d)Active Control1 Intervention
The low-dose vitamin K group will take one 90-mcg vitamin K2 (menaquinone-7) softgel capsule and one placebo softgel capsule every day for 8 weeks.
Group II: High-Dose Vitamin K2 (180-mcg/d)Active Control1 Intervention
The high-dose vitamin K group will take two 90-mcg vitamin K2 (menaquinone-7) softgel capsules every day for 8 weeks.
Group III: Placebo-ControlPlacebo Group1 Intervention
The placebo-control group will take two placebo softgel capsules every day for 8 weeks.

Find a Location

Who is running the clinical trial?

Yale UniversityOTHER
1,924 Previous Clinical Trials
3,031,628 Total Patients Enrolled
26 Trials studying Insulin Resistance
5,381 Patients Enrolled for Insulin Resistance
Tufts UniversityOTHER
270 Previous Clinical Trials
594,861 Total Patients Enrolled
5 Trials studying Insulin Resistance
290 Patients Enrolled for Insulin Resistance
Augusta UniversityLead Sponsor
215 Previous Clinical Trials
85,660 Total Patients Enrolled
2 Trials studying Insulin Resistance
60 Patients Enrolled for Insulin Resistance
~3 spots leftby Dec 2025
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