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Stress Challenge for Myocardial Ischemia (MIMS3 Trial)

N/A

Waitlist Available

Led By Viola Vaccarino, MD, PhD

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≤60 at the time of MI

Be between 18 and 65 years old

Must not have

Severe aortic stenosis

Weight ≥ 360 pounds and/or body mass index (BMI) of 40 or greater (weight limit of the SPECT imaging table)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

No Placebo-Only Group

Summary

This trial looks at how stress affects heart disease in men and women. It involves one clinic visit, a week of at-home monitoring, and follow-up phone calls every six months for three years.

Who is the study for?

This trial is for men and women aged 60 or younger who had a heart attack within the last 8 months. It's not suitable for those with recent severe heart issues, high blood pressure on test day, current use of certain psychotropic drugs (except antidepressants), pregnant or breastfeeding women, people over 360 pounds or with a BMI of 40+, and individuals with other serious health problems.

What is being tested?

The study investigates how emotional stress affects heart disease in different genders. Participants will have one clinic visit, monitor their condition at home for a week, and receive follow-up calls every six months over three years to track their heart health under stress.

What are the potential side effects?

Since this trial involves monitoring reactions to stress rather than medication, there are no direct side effects from drugs being tested. However, participants may experience stress-related symptoms during the study.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 60 years old or younger and have had a heart attack.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a severe narrowing of the main heart valve.

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I weigh at least 360 pounds or my BMI is 40 or higher.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Cardiovascular Events

Secondary study objectives

Cardiovascular Death

Cardiovascular Events Excluding Heart Failure

Myocardial Infarction or Cardiovascular Death

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Young Participants with Prior MIExperimental Treatment1 Intervention

Participants aged 60 or less who experienced a MI within the last 8 months will undergo a stress challenge to assess MSI and will then be followed for 3 years.

0 / 3Eligibility criteria met