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Procedure

Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis

N/A
Waitlist Available
Led By Timothy W Meyer, MD
Research Sponsored by Palo Alto Veterans Institute for Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.

Eligible Conditions
  • Kidney Failure

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: high dialysate flow, larger dialyzerExperimental Treatment1 Intervention
high dialysate flow, larger dialyzer
Group II: low dialysate flow, smaller dialyzerActive Control1 Intervention
low dialysate flow, smaller dialyzer

Find a Location

Who is running the clinical trial?

Palo Alto Veterans Institute for ResearchLead Sponsor
56 Previous Clinical Trials
8,602 Total Patients Enrolled
1 Trials studying Kidney Failure
17 Patients Enrolled for Kidney Failure
Timothy W Meyer, MDPrincipal InvestigatorPAIRE
1 Previous Clinical Trials
30 Total Patients Enrolled
~2 spots leftby Jan 2026
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