Hematopoiesis for Chronic Lymphocytic Leukemia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how bone marrow (the soft tissue inside bones that produces blood cells) is affected in individuals with MBL (a condition with low levels of abnormal blood cells) and CLL (a type of blood cancer) compared to healthy individuals. The goal is to understand how these conditions alter the body's ability to fight infections. Participants will provide blood samples and may undergo a bone marrow biopsy (a small sample taken from the bone). This trial suits those diagnosed with MBL or CLL, regardless of treatment history, as well as healthy individuals over 40 without these conditions.
As an unphased trial, this study allows participants to contribute to foundational research that could enhance understanding and treatment of MBL and CLL.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop your current medications. It includes people who are currently being treated, so you might be able to continue your medications.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover new insights into how blood formation, or hematopoiesis, differs in patients with Monoclonal B-cell Lymphocytosis (MBL) and Chronic Lymphocytic Leukemia (CLL) compared to healthy individuals. Unlike current treatments that primarily focus on managing symptoms or slowing disease progression, this study seeks to understand the underlying biological processes. By comparing blood and bone marrow samples from patients and healthy controls, researchers hope to identify potential new targets for future therapies, paving the way for more personalized and effective treatment strategies.
Who Is on the Research Team?
Neil E. Kay, M.D.
Principal Investigator
Mayo Clinic in Rochester
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observational
Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study
Follow-up
Participants are monitored for safety and effectiveness after observational procedures
What Are the Treatments Tested in This Trial?
Interventions
- Non-Interventional Study
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo blood sample collection and bone marrow aspiration and biopsy and have their medical records reviewed on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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