Transcranial Magnetic Stimulation for Word-Finding Difficulty
(CSST Trial)

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: University of South Carolina

Disqualifiers: Dementia, Alcohol abuse, Psychiatric, others

No Placebo Group

Trial Summary

What is the purpose of this trial?This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).

Eligibility Criteria

This trial is for native English speakers aged 18 to 40 who have difficulty finding words. It's not suitable for left-handed individuals, those with dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or severe vision/hearing issues that could affect task performance.

Inclusion Criteria

I am a native English speaker.

I am between 18 and 40 years old.

Exclusion Criteria

Contraindication to TMS as determined by a standard TMS screening form

Contraindication to MRI as determined by a standard MRI screening form

Left-handed participants

+1 more

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo a structural MRI scan for TMS target localization

1 week

1 visit (in-person)

TMS and Task Performance

Participants perform lexical, semantic, and number judgment tasks with TMS applied at different time points

30 minutes per session

Multiple sessions (in-person)

Follow-up

Participants are monitored for any delayed effects of TMS and data analysis is conducted

4 weeks

Participant Groups

The study is testing how a single pulse of Transcranial Magnetic Stimulation (TMS) affects the activation timing of the left anterior temporal lobe during word processing tasks.

1Treatment groups

Experimental Treatment

Group I: TMSExperimental Treatment1 Intervention