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APAP and NAC combination for Acute Liver Failure

N/A
Waitlist Available
Led By Matthew Chang, MD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 24 hours of study drug administration
Awards & highlights
Approved for 10 Other Conditions
All Individual Drugs Already Approved

Summary

The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as an anti-pyretic agent.

Eligible Conditions
  • Prevention and Control
  • Hepatotoxicity
  • Acute Liver Failure
  • Liver Failure
  • Fever

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 24 hours of study drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 24 hours of study drug administration for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Difference in liver function tests after study drug administration between participants who are administered combination N-acetyl-p-aminophenol and N-Acetylcysteine (APAP-NAC) versus combination APAP-placebo

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: APAP and NAC combinationExperimental Treatment1 Intervention
N-acetyl-p-aminophenol and placebo (APAP-NAC) combination pill
Group II: APAP and Placebo combinationPlacebo Group1 Intervention
N-acetyl-p-aminophenol and placebo (APAP-placebo) combination pill

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Who is running the clinical trial?

Columbia UniversityLead Sponsor
1,490 Previous Clinical Trials
2,663,964 Total Patients Enrolled
Matthew Chang, MDPrincipal InvestigatorColumbia University
~0 spots leftby Dec 2025
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