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APAP and NAC combination for Fever

N/A
Waitlist Available
Led By Matthew Chang, MD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 hours after study drug administration
Awards & highlights

Study Summary

The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as an anti-pyretic agent.

Eligible Conditions
  • Fever
  • Liver Injury
  • Prevention and Control
  • Liver Failure
  • Acute Liver Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 hours after study drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 hours after study drug administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference in temperature reduction between participants who are administered combination N-acetyl-p-aminophenol and N-Acetylcysteine (APAP-NAC) versus combination APAP-placebo
Secondary outcome measures
Difference in liver function tests after study drug administration between participants who are administered combination N-acetyl-p-aminophenol and N-Acetylcysteine (APAP-NAC) versus combination APAP-placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: APAP and NAC combinationExperimental Treatment1 Intervention
N-acetyl-p-aminophenol and placebo (APAP-NAC) combination pill
Group II: APAP and Placebo combinationPlacebo Group1 Intervention
N-acetyl-p-aminophenol and placebo (APAP-placebo) combination pill

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Who is running the clinical trial?

Columbia UniversityLead Sponsor
1,448 Previous Clinical Trials
2,531,490 Total Patients Enrolled
5 Trials studying Fever
2,087 Patients Enrolled for Fever
Matthew Chang, MDPrincipal InvestigatorColumbia University
~0 spots leftby Jun 2025
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