Risk Assessment for Lung Cancer

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: City of Hope Medical Center

Disqualifiers: Unable to consent, recent chest imaging

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to identify factors, both biological like genetics and social like environment, that might increase lung cancer risk in people who have never smoked. Participants will complete surveys, provide blood samples, and may undergo a low-dose CT scan to gather information that could enhance early detection of lung cancer. The trial suits those with lung cancer but no smoking history, a strong family history of lung cancer, or genetic risk factors. Participants who have not been diagnosed with lung cancer in the past five years and meet certain risk profiles are also eligible.

As an unphased study, this trial offers participants the chance to contribute to groundbreaking research that could lead to improved prevention and detection strategies for lung cancer.

Why are researchers excited about this trial?

Researchers are excited about this trial because it aims to better understand lung cancer risk and its causes through a comprehensive approach. Unlike standard diagnostic methods, this trial combines data from surveys, medical records, blood samples, and low-dose CT scans to gain a holistic view of an individual's risk factors. This multi-faceted approach could lead to earlier detection and more personalized prevention strategies, potentially improving outcomes for those at risk of lung cancer.

Who Is on the Research Team?

Stacy W Gray

Principal Investigator

City of Hope Medical Center

Are You a Good Fit for This Trial?

Inclusion Criteria

I have a genetic change linked to a higher risk of lung cancer.

My family has a strong history of lung cancer.

I am of East Asian descent and have a family history of lung cancer.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants complete a survey and undergo collection of blood samples and medical record review

1 day

1 visit (in-person)

CT Screening

Participants not diagnosed with lung cancer undergo a low-dose CT scan

20 minutes

1 visit (in-person)

Follow-up

Participants are monitored for lung cancer incidence and other outcomes through study completion

5 years

What Are the Treatments Tested in This Trial?

How Is the Trial Designed?

Group I: Observational (survey, biospecimen, medical record, CT) Experimental Treatment 4 Interventions

Participants complete a survey over 40-45 minutes at baseline. Participants' medical records are also reviewed. Participants who have lung cancer but have not undergone treatment and participants not diagnosed with lung cancer (i.e., "unaffected"), undergo collection of blood samples at a scheduled clinical or research blood draw. Participants not diagnosed with lung cancer (i.e. "unaffected"), undergo a low-dose CT scan over 20 minutes.

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials

614

Recruited

1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+