Deep Functional Phenotyping of the ALA Lung Health Cohort

(DLP-LHC Trial)

Recruiting at 11 trial locations

Overseen By Alexis Rea, MPH

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Johns Hopkins University

Must not be taking: High-dose inhalers

Disqualifiers: Severe asthma, Chronic lung disease, Pregnancy, Cancer, Cardiovascular diseases, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

1000 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to study lung health in 1,000 healthy individuals to understand how body structure, environment, and overall health impact lung function. Researchers will explore lung airflow, size, blood vessel structure, and gas exchange ability. Participants will undergo four different tests to measure lung function. Individuals who have lived in the U.S. for at least a year and do not have severe asthma or chronic lung diseases are suitable candidates. As an unphased study, this trial allows participants to contribute to valuable research that could enhance understanding of lung health for future generations.

Why are researchers excited about this trial?

Researchers are excited about the Deep Functional Phenotyping of the ALA Lung Health Cohort trial because it aims to uncover intricate details about lung health that current methods might miss. Unlike typical treatments focusing on managing symptoms of lung diseases, this approach seeks to understand the full spectrum of lung function variations in healthy individuals over time. By deeply analyzing these variations, the trial could reveal early indicators of lung disease, leading to earlier and more precise interventions. This innovative perspective could revolutionize how we predict, diagnose, and treat lung conditions, potentially improving outcomes long before symptoms develop.

Who Is on the Research Team?

Meredith McCormack, MD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

Inclusion Criteria

You are between 25 and 35 years old when the study starts.

You can read and understand English or Spanish.

You have lived in the United States for at least 12 months before the check-up.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline assessments including lung function tests and CT scans to measure lung structure and function

1-2 weeks

1 visit (in-person)

Observational Study

Participants are observed for associations between lung structure/function and modifiable exposures and risk factors

Ongoing

Follow-up

Participants are monitored for changes in lung health and function over time

6 months

What Are the Treatments Tested in This Trial?

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials

2,366

Recruited

15,160,000+

University of Vermont

Collaborator

Trials

283

Recruited

3,747,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials

3,987

Recruited

47,860,000+

American Lung Association

Collaborator

Trials

32

Recruited

11,000+