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Curcumin Therapy for COPD
N/A
Waitlist Available
Led By Oleg Sostin, MD
Research Sponsored by Danbury Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Summary
This trial tests if curcumin, a substance from turmeric, can help people with COPD by reducing lung inflammation. The study targets COPD patients who still suffer from severe symptoms and frequent hospital visits despite current treatments.
Who is the study for?
This trial is for individuals with COPD who have smoked at least 10 pack-years, have specific lung function test results, and haven't had a flare-up in the last month. They must not use turmeric recently or be on certain medications, pregnant, lactating, or unable to do a walking test due to non-COPD issues.
What is being tested?
The study tests if curcumin therapy improves COPD management over 90 days compared to placebo. All participants will continue their usual care. The effects of curcumin are measured against those receiving an inactive substance in this double-blind setup where neither doctors nor patients know who's getting what.
What are the potential side effects?
Curcumin is generally considered safe but may cause digestive upset like nausea or diarrhea in some people. Since it's being tested alongside standard treatments for COPD, other side effects could include typical reactions to those existing medications.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
St. George's Respiratory Questionnaire (SGRQ-C) score
Secondary study objectives
Performance on the 6-minute walk test (6MWT)
Relative risk of hospital admission for acute COPD exacerbation.
Chronic Obstructive Airway Disease
+1 moreTrial Design
2Treatment groups
Active Control
Group I: Active Comparator: Placebo with Standard COPD careActive Control2 Interventions
Subjects will be given instructions to take 1 capsule twice daily for 90 days, 30 min before or 1 hour after meals, with a glass of water; if they develop upset stomach or diarrhea, then to take the medication with meals. This treatment will be in addition to the usual care that the hospital physician prescribe for them to treat the COPD.
Group II: Active Comparator: Curcumin therapy added to standard COPD careActive Control2 Interventions
Subjects will be given instructions to take 1 capsule twice daily for 90 days, 30 min before or 1 hour after meals, with a glass of water; if they develop upset stomach or diarrhea, then to take the medication with meals. This treatment will be in addition to the usual care that the hospital physician prescribe for them to treat the COPD.
Find a Location
Who is running the clinical trial?
Danbury HospitalLead Sponsor
10 Previous Clinical Trials
1,239 Total Patients Enrolled
Oleg Sostin, MDPrincipal InvestigatorDanbury Hospital, Nuvance Health
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have used turmeric as a spice or supplement within the last 3 months before joining the study.You have taken steroids for a short period within 4 weeks before starting the trial.You have been diagnosed with COPD, which is a lung condition related to smoking, and have specific breathing test results.You are currently taking certain medications like chemotherapy drugs, tacrolimus, talinolol, or sulfasalazine.You cannot walk for six minutes due to a reason not related to COPD.The patient cannot complete the SGRQ-C questionnaire in their preferred language.
Research Study Groups:
This trial has the following groups:- Group 1: Active Comparator: Placebo with Standard COPD care
- Group 2: Active Comparator: Curcumin therapy added to standard COPD care
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.