Chest X-ray Tomosynthesis for Lung Cancer

Overseen By Alexander Cypro, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of California, San Diego

Disqualifiers: Prior lung cancer treatment

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

1000 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether chest X-ray tomosynthesis, an advanced imaging technique, can effectively detect lung cancer compared to standard CT scans. It also aims to develop AI tools to identify lung cancer in these images. The trial seeks participants undergoing lung cancer screenings, those being evaluated for suspicious lung nodules, or individuals recently diagnosed with lung cancer. Participants will receive a chest tomosynthesis scan alongside their standard CT scan to compare the two methods. As a Phase 2 trial, this research measures the imaging method's effectiveness in an initial, smaller group, offering participants a chance to contribute to advancements in lung cancer detection.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that chest X-ray tomosynthesis is safe for lung cancer screening?

Research has shown that chest X-ray tomosynthesis is generally easy for patients to handle. This method uses less radiation than a standard CT scan, making it a safer option. Studies have found that although CT scans excel at detecting lung nodules, they expose patients to more radiation. In contrast, chest X-ray tomosynthesis offers reduced exposure. So far, no major reports of side effects have been directly linked to chest X-ray tomosynthesis in clinical settings, suggesting it is a safe choice for lung cancer screening. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about chest X-ray tomosynthesis for lung cancer screening because it offers a potentially more detailed and accurate imaging method compared to standard chest X-rays and CT scans. Unlike traditional X-rays that produce a single flat image, tomosynthesis creates a 3D reconstruction of the chest, providing clearer views of lung structures. This could lead to earlier and more accurate detection of lung nodules, improving outcomes for patients by catching potential cancers sooner. Additionally, tomosynthesis generally involves lower radiation exposure than a CT scan, making it a safer option for regular screening.

What evidence suggests that chest tomosynthesis is effective for detecting lung cancer?

This trial will evaluate the effectiveness of chest X-ray tomosynthesis in participants who have recently undergone a routine clinical chest computed tomography scan for lung cancer screening or evaluation of nodules suspicious for lung cancer. Studies have shown that digital chest tomosynthesis surpasses standard chest X-rays in detecting small lung spots, known as nodules, identifying 91% of nodules that are 4 to 6 millimeters in size. Early detection of lung nodules is crucial for catching lung cancer sooner. Compared to CT scans, tomosynthesis uses less radiation, potentially making it a safer choice for regular check-ups. Although CT scans remain more effective for detecting lung cancer, tomosynthesis offers a promising option with better safety and fewer risks. ^{1 2 3 4 6}

Who Is on the Research Team?

Albert Hsiao, MD PhD

Principal Investigator

UC San Diego, Department of Radiology

Are You a Good Fit for This Trial?

Inclusion Criteria

I am currently getting screened for lung cancer.

I am being checked for a suspicious lung spot.

I have recently been diagnosed with lung cancer.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo chest X-ray tomosynthesis and routine clinical chest CT scan for lung cancer screening or evaluation of suspicious nodules

1 day

1 visit (in-person)

Follow-up

Participants are monitored for diagnostic accuracy of chest tomosynthesis in identifying lung cancer and nodules

through 12/31/2026

What Are the Treatments Tested in This Trial?

Interventions

• Chest X-ray Tomosynthesis

How Is the Trial Designed?

Group I: Chest X-ray Tomosynthesis Participants Experimental Treatment 1 Intervention

Participants who had a recent, routine clinical chest computed tomography scan for lung cancer screening or evaluation of nodule suspicious for lung cancer will undergo an additional chest X-ray tomosynthesis scan.

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials

1,215

Recruited

1,593,000+

AIxSCAN, Inc.

Collaborator

Trials

1

Recruited

1,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT06577883

Next Generation Chest X-Ray Tomosynthesis for ... We will determine the effectiveness of CXRT for detecting lung cancer in this population, evaluating its sensitivity and specificity for ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11225395/

Next-generation digital chest tomosynthesis - PMC Large trials have shown that CT is superior to X-ray for the detection of lung nodules, but CT has drawbacks, including a higher radiation dose ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S1556086415328422

Lung Cancer Detection with Digital Chest Tomosynthesis As a potential alternative, DT has been shown to be superior to chest radiography in the detection of pulmonary nodules,: it detected 91% of nodules between 4 ...

4. clinicaltrials.ucsd.edu clinicaltrials.ucsd.edu/trial/NCT06577883

UCSD Lung Cancer Trial → Next Generation Chest X-Ray ... We will determine the effectiveness of CXRT for detecting lung cancer in this population, evaluating its sensitivity and specificity for ...

5. connect.careboxhealth.com connect.careboxhealth.com/en-US/trial/listing/536757

Next Generation Chest X-Ray Tomosynthesis for Screening of ... Researchers will compare chest tomosynthesis images to computed tomography scans for each participant to see how they compare in diagnosing lung cancer.

6. sciencedirect.com sciencedirect.com/science/article/pii/S1076633218302435

Detection of Pulmonary Nodule Growth with Chest ... The generated nodule templates are virtually placed in 3D space at locations corresponding to desired positions within the lung parenchyma of the patient.