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Theta-burst Stimulation for Memory Improvement in Mild Cognitive Impairment

N/A

Recruiting

Led By Nanthia Suthana

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

55-90 years of age

Diagnosis of mild neurocognitive disorder according to DSM-5 criteria

Must not have

Diagnosis of dementia

Active major psychiatric or neurologic disorders associated with neurocognitive impairment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline: day 2; during stimulation: day 3, day 7, day 12, day 17; follow-up appointments: day 18, day 19, day 20.

Summary

This trial is testing whether transcranial magnetic stimulation can help improve memory for people with mild cognitive impairment. The study will enroll people with MCI who will be randomly assigned to receive active or sham brain stimulation, where they won't know if they're receiving the real treatment or not.

Who is the study for?

This trial is for individuals aged 55-90 with mild cognitive impairment, who are in good health, right-handed, and speak English fluently. They should have memory complaints verified by specific tests and be able to consent to a long-term study. Excluded are those with dementia, major psychiatric or neurological disorders, substance abuse issues, certain medication use, or contraindications to MRI.

What is being tested?

The trial examines whether brain stimulation using transcranial magnetic stimulation (TMS) can improve memory in people with mild cognitive impairment. Participants will be randomly assigned to receive either active TMS or sham (fake) treatment without knowing which one they're getting.

What are the potential side effects?

While the description doesn't specify side effects of Theta Burst Stimulation directly, common ones from similar procedures may include headache, scalp discomfort at the site of stimulation, lightheadedness or seizures in very rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 55 and 90 years old.

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I have been diagnosed with mild cognitive impairment.

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I live on my own without needing daily help.

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I can perform most daily activities without help.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been diagnosed with dementia.

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I do not have major psychiatric or neurological disorders affecting my thinking.

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I have never had a stroke, traumatic brain injury, epilepsy, Huntington's, or Parkinson's.

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I do not speak English.

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I have undergone TMS treatment before.

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I have not had a head injury or diseases affecting my brain.

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I have high blood pressure or heart disease that is not well-managed.

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I am currently taking medication for muscle spasms or bladder issues.

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I am currently taking a sedating antihistamine like Benadryl.

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I am not taking medications like certain antidepressants that have strong anticholinergic or antihistaminic effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline: day 2; during stimulation: day 3, day 7, day 12, day 17; follow-up appointments: day 18, day 19, day 20.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline: day 2; during stimulation: day 3, day 7, day 12, day 17; follow-up appointments: day 18, day 19, day 20.

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline: day 2; during stimulation: day 3, day 7, day 12, day 17; follow-up appointments: day 18, day 19, day 20. for reporting.