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Transcranial Magnetic Stimulation for Episodic Memory

N/A
Recruiting
Research Sponsored by Boston College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Ages 18 to 35 years old
Free of major neurological or psychiatric illness
Must not have
History of neurological disorder or brain injury, including family history of epilepsy, convulsions or seizures, stroke; vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication, and any unexplained lifetime loss of consciousness/syncope
History of heart disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up functional connectivity will be assessed during the hour following stimulation.
Awards & highlights

Summary

This trial aims to study how the brain supports memory in young adults. They will use a non-invasive technique called transcranial magnetic stimulation to alter brain activity in memory-related regions. Memory and brain

Who is the study for?
This trial is for healthy, right-handed adults aged 18 to 35 who speak English fluently and have normal vision (with or without correction). It's not suitable for those with major neurological or psychiatric illnesses.
What is being tested?
The study tests how transcranial magnetic stimulation (TMS) affects brain activity related to episodic memory. Participants will undergo TMS, behavioral testing, and MRI scans to see how this influences memory and brain network interactions.
What are the potential side effects?
TMS may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in rare cases. The MRI might lead to claustrophobia or discomfort from lying still.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 35 years old.
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I do not have any major neurological or psychiatric illnesses.
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My vision is normal or corrected to normal with glasses or contacts.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have no history of brain injuries, seizures, or unexplained loss of consciousness.
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I have a history of heart disease.
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I have had brain surgery in the past.
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I am currently taking medication that can affect my hearing.
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I have hearing loss caused by loud noise exposure.
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I cannot stay still for an hour due to uncontrollable shaking.
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I do not have any implants or conditions that make MRI scans unsafe for me.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~tasks will be completed during the hour following stimulation.
This trial's timeline: 3 weeks for screening, Varies for treatment, and tasks will be completed during the hour following stimulation. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Accuracy on tests of episodic memory
Task-related functional connectivity among posterior medial brain regions

Trial Design

1Treatment groups
Experimental Treatment
Group I: All participantsExperimental Treatment1 Intervention
All participants will complete all experimental conditions, which include transcranial magnetic stimulation (continuous theta-burst stimulation) to a brain region of experimental interest and to a control brain region.

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Who is running the clinical trial?

Boston CollegeLead Sponsor
39 Previous Clinical Trials
49,020 Total Patients Enrolled
~9 spots leftby Dec 2024
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