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Behavioral Intervention

Cognitive Enhancement Therapy vs. Social Skills Training for Mental Illness

N/A

Recruiting

Led By Matcheri S Keshavan, MD

Research Sponsored by Beth Israel Deaconess Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 to 65

DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder (confirmed via the MINI diagnostic interview)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measurement at 0, 6, 12, 18, 24 months

Awards & highlights

No Placebo-Only Group

Summary

This trial is comparing two different treatments to see which is more effective in improving community functioning.

Who is the study for?

This trial is for adults aged 18 to 65 with a diagnosis of schizophrenia or related disorders, who have an IQ over 70. It's not suitable for those with brain syndromes, intellectual disabilities, or recent participation in the therapies being tested.

What is being tested?

The study compares Cognitive Enhancement Therapy (CET) and Social Skills Training (SST), both known to improve community functioning in people with serious mental illness. Mental health centers are randomly chosen to use either CET or SST.

What are the potential side effects?

Since CET and SST are non-medical treatments focusing on cognitive skills and social abilities, they may cause fatigue or emotional distress but do not have typical drug-related side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 65 years old.

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I have been diagnosed with schizophrenia or a related disorder.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measurement at 0, 6, 12, 18, 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measurement at 0, 6, 12, 18, 24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and measurement at 0, 6, 12, 18, 24 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in Heinrich Quality of Life Scale

Change in Social Adjustment Scale II

Change in Social Skills Performance Assessment

Secondary study objectives

Change in Auditory Verbal Learning Test

Change in List Sorting Working Memory

Change in Managing Emotions

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Enhancement TherapyExperimental Treatment1 Intervention

CET is a comprehensive manualized cognitive remediation program designed to maximize gains in social functioning by integrating computer-based training to enhance neurocognition with group-based exercises to improve social cognition.

Group II: Social Skills TrainingActive Control1 Intervention

The HOPES social rehabilitation program uses the principles of SST (modeling, role playing, positive and corrective feedback, homework assignments, in vivo skills practice), designed to improve both psychosocial functioning and preventive health..

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cognitive Enhancement Therapy

2012

N/A

~160

0 / 2Eligibility criteria met