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Behavioural Intervention

Inactive for Metabolic Diseases

N/A
Recruiting
Research Sponsored by Concordia University Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline; 20 and 40, and 60 minutes into exercise; and every 30 minutes after exercise up to 4 hours
Awards & highlights

Study Summary

This trial is looking at how sitting too much can affect the body's response to exercise. The American Heart Association recommends exercising for at least 150 minutes per week to stay healthy. However, sitting for

Who is the study for?
This trial is for individuals who are interested in how a day of sitting affects muscle response to exercise and energy use during and after cycling. Participants should be able to complete one day with less than 5,000 steps followed by an hour of biking. The study requires blood samples and muscle biopsies before and after exercise.Check my eligibility
What is being tested?
The study investigates the impact of a sedentary day on muscles' ability to respond to aerobic exercise, specifically cycling. It measures changes in carbohydrate and fat burning during and post-exercise through blood tests and muscle tissue analysis.See study design
What are the potential side effects?
Potential side effects may include discomfort or bruising from blood sample collection, soreness or risk of infection at the biopsy site where muscle tissue is collected, as well as general fatigue from the exercise.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline; 20 and 40, and 60 minutes into exercise; and every 30 minutes after exercise up to 4 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline; 20 and 40, and 60 minutes into exercise; and every 30 minutes after exercise up to 4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Basal and post-exercise gene expression with inactivity
Circulating lipid and carbohydrate metabolism

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: InactiveExperimental Treatment1 Intervention
Subjects will be asked to be sedentary prior to an acute exercise bout (<5,000 steps as measured by a physical activity monitor).
Group II: Normal activityPlacebo Group1 Intervention
Subjects will be asked to have normal activity prior to an acute exercise bout (>8,500 steps as measured by a physical activity monitor).

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Who is running the clinical trial?

Concordia University WisconsinLead Sponsor
3 Previous Clinical Trials
182 Total Patients Enrolled
~7 spots leftby Dec 2025
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