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Dietary Supplement

Fat Effects in Women With Metabolic Syndrome (FEMMES II Trial)

N/A
Waitlist Available
Led By Pathmaja Paramsothy, MD, MS
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up four hours
Awards & highlights
No Placebo-Only Group

Summary

Among 10 premenopausal women with Metabolic Syndrome: Specific Aim 1: Compare the effects of acute fat feeding on flow mediated dilation (FMD) as measured by brachial artery reactivity among three fat challenges (saturated fat vs. monounsaturated fat (MUFA) vs. polyunsaturated fat (PUFA)at 4 hours post feeding. Hypothesis Saturated fat feeding will impair FMD but MUFA and PUFA feeding will not. Specific Aim 2: Compare the effects of acute feeding on vascular inflammation as measured by VCAM and sICAM among three fat challenges at 3 1/2 hours post feeding. Hypothesis: Saturated fat feeding will increase vascular inflammation but MUFA and PUFA will not.

Eligible Conditions
  • Metabolic Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~four hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and four hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Flow Mediated Dilation at 4 hours post feeding

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: young women with MetSExperimental Treatment1 Intervention
1. Saturated fat (control) 2. n-3 Polyunsaturated fat (experimental) 3. monounsaturated fat

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Who is running the clinical trial?

University of WashingtonLead Sponsor
1,826 Previous Clinical Trials
1,906,131 Total Patients Enrolled
8 Trials studying Metabolic Syndrome
728 Patients Enrolled for Metabolic Syndrome
Pathmaja Paramsothy, MD, MSPrincipal InvestigatorUniversity of Washington
~1 spots leftby Dec 2025
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