Age: 18 - 65
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: University of Chicago
No Placebo Group
Trial Summary
What is the purpose of this trial?The purpose of this study is to understand how daily rhythms of behavior affect the expression of genes in fat cells, and how these daily cycles affect the way fat cells respond to insulin (a hormone that controls blood sugar levels) before and after bariatric surgery.
Eligibility Criteria
This trial is for obese women aged 18-55 with a BMI over 40, scheduled for bariatric surgery at the University of Chicago. It's not open to those allergic to lidocaine, with uncontrolled high blood pressure, recent surgery or clinical study participation, lactating or post-menopausal women, men, beta blocker users, pregnant individuals, or anyone with certain serious illnesses.Inclusion Criteria
I am between 18 and 55 years old.
I am female.
You are not significantly overweight.
+8 more
Exclusion Criteria
I have been diagnosed with a disease affecting my heart, kidneys, liver, or cancer.
You are allergic to lidocaine.
My blood pressure is controlled and below 140/90 mmHg without medication.
+7 more
Participant Groups
The study aims to understand how daily behaviors influence gene expression in fat cells and insulin response before and after bariatric surgery by focusing on circadian clock control and alignment.
3Treatment groups
Experimental Treatment
Active Control
Group I: Circadian Clock Alignment - High BMIExperimental Treatment1 Intervention
Subjects will come to the Sleep Lab three nights before their bariatric surgery procedure for an intervention that will align their central circadian clock. The intervention includes eating meals and snacks at fixed times and having lights off at a specific time at night and lights on at a specific time in the morning.
Group II: Circadian Clock Control - High BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.
Group III: Circadian Clock Control - Low BMIActive Control1 Intervention
Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of ChicagoChicago, IL
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Who Is Running the Clinical Trial?
University of ChicagoLead Sponsor