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Polyphenols

Raspberry Supplement for Metabolic Syndrome

N/A

Waitlist Available

Led By Marie-Claude Vohl

Research Sponsored by Laval University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

At least one of the following: BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men

Be between 18 and 65 years old

Must not have

Surgery in the last 3 months or planned during the study

Use of antibiotics in the last 3 months

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trial will study the effects of raspberries on the gut microbiota and intestinal integrity to see if they can help prevent obesity-linked metabolic syndrome.

Who is the study for?

This trial is for men and premenopausal women in good health with a BMI between 25-40 or waist size over 80 cm for women and 94 cm for men, plus high triglycerides or fasting insulin. Participants must be Caucasian without significant weight change recently, no raspberry allergies/intolerances, low alcohol consumption, not on certain diets or medications that could affect the study.

What is being tested?

The trial is testing if raspberry supplements can help improve gut bacteria and prevent obesity-related metabolic syndrome. It involves studying changes in participants' gut microbiota, gene expression related to metabolism (transcriptomics), and small molecules produced by cells (metabolomics) after taking the supplement.

What are the potential side effects?

Potential side effects are not detailed but may include typical reactions to dietary supplements such as digestive discomfort. Since raspberries are generally considered safe to eat, severe side effects are unlikely; however individual tolerances vary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My BMI is between 25 and 40, or my waist size meets the required measurements.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had surgery in the last 3 months or will have during the study.

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I have not taken antibiotics in the last 3 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Experimental: Raspberry supplementationExperimental Treatment1 Intervention

Dietary Supplement: 280g of frozen raspberries, taken daily for 8 weeks. Subjects will consume frozen raspberry to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and control group (without raspberry).

Group II: ControlActive Control1 Intervention

Control: follow their usual diet (control group). Subjects will follow their usual diet and not consume raspberry to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the experimental group (with raspberry).

0 / 3Eligibility criteria met