Raspberry Supplement for Metabolic Syndrome

Recruiting in Palo Alto (17 mi)

Overseen byMarie-Claude Vohl

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Laval University

No Placebo Group

Trial Summary

What is the purpose of this trial?

There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effects of raspberry on obesity and the metabolic syndrome can be linked to their potential impact on the gut microbiota and intestinal integrity remains speculative at this time. Moreover, the mechanisms of action underlying health benefits associated to raspberry consumption are still unknown. The investigators are thus proposing to combine the study of metagenomics, transcriptomics and metabolomics to test whether a prebiotic activity of raspberry can play a role in the prevention of obesity-linked metabolic syndrome in a clinical setting.

Eligibility Criteria

This trial is for men and premenopausal women in good health with a BMI between 25-40 or waist size over 80 cm for women and 94 cm for men, plus high triglycerides or fasting insulin. Participants must be Caucasian without significant weight change recently, no raspberry allergies/intolerances, low alcohol consumption, not on certain diets or medications that could affect the study.

Inclusion Criteria

People of European descent

Your triglyceride levels are higher than 1.35 mmol/L or your fasting insulin levels are higher than 42 pmol/L.

I am a healthy man or a woman who has not gone through menopause.

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Exclusion Criteria

You don't like the taste of raspberries.

I have had surgery in the last 3 months or will have during the study.

You have gained or lost more than 5% of your body weight in the last 3 months.

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Treatment Details

Interventions

Raspberry supplement (Polyphenols)

Trial OverviewThe trial is testing if raspberry supplements can help improve gut bacteria and prevent obesity-related metabolic syndrome. It involves studying changes in participants' gut microbiota, gene expression related to metabolism (transcriptomics), and small molecules produced by cells (metabolomics) after taking the supplement.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Experimental: Raspberry supplementationExperimental Treatment1 Intervention

Dietary Supplement: 280g of frozen raspberries, taken daily for 8 weeks. Subjects will consume frozen raspberry to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and control group (without raspberry).

Group II: ControlActive Control1 Intervention

Control: follow their usual diet (control group). Subjects will follow their usual diet and not consume raspberry to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the experimental group (with raspberry).